eprintid: 10056350
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/05/63/50
datestamp: 2018-09-19 14:39:16
lastmod: 2021-09-17 22:23:39
status_changed: 2018-09-19 14:39:16
type: article
metadata_visibility: show
creators_name: Flatt, T
creators_name: Partridge, L
title: Horizons in the evolution of aging
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F99
keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, NEMATODE CAENORHABDITIS-ELEGANS, LIFE-HISTORY EVOLUTION, FECUNDITY/LONGEVITY TRADE-OFF, AFRICAN TURQUOISE KILLIFISH, AGE-RELATED DISEASE, LONG-LIVED MUTANTS, GROWTH-FACTOR-I, NAKED MOLE-RAT, DROSOPHILA-MELANOGASTER, INSULIN-RECEPTOR
note: This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
abstract: Between the 1930s and 50s, evolutionary biologists developed a successful theory of why organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evolves due to mutation accumulation or a benefit to fitness early in life. Here we review major insights and challenges that have emerged over the last 35 years: selection does not always necessarily decline with age; higher extrinsic (i.e., environmentally caused) mortality does not always accelerate aging; conserved pathways control aging rate; senescence patterns are more diverse than previously thought; aging is not universal; trade-offs involving lifespan can be ‘broken’; aging might be ‘druggable’; and human life expectancy continues to rise but compressing late-life morbidity remains a pressing challenge.
date: 2018-08-20
date_type: published
publisher: BMC
official_url: https://doi.org/10.1186/s12915-018-0562-z
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Review
verified: verified_manual
elements_id: 1582040
doi: 10.1186/s12915-018-0562-z
lyricists_name: Partridge, Linda
lyricists_id: LPART24
actors_name: Partridge, Linda
actors_name: Wright, Michael
actors_id: LPART24
actors_id: MWRIG83
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: BMC Biology
volume: 16
article_number: 93
pages: 13
issn: 1741-7007
citation:        Flatt, T;    Partridge, L;      (2018)    Horizons in the evolution of aging.                   BMC Biology , 16     , Article 93.  10.1186/s12915-018-0562-z <https://doi.org/10.1186/s12915-018-0562-z>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10056350/1/12915_2018_Article_562.pdf