@article{discovery10066114, pages = {454--461}, journal = {ChemMedChem}, volume = {14}, note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.}, number = {4}, year = {2019}, title = {Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection}, publisher = {Wiley-VCH Verlag}, month = {February}, abstract = {A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in-vitro cell culture approach. This approach led to the development of nanomolar active compounds with low toxicity.}, url = {https://doi.org/10.1002/cmdc.201800718}, issn = {1860-7179}, keywords = {Pentathiepin, Feline Immunodeficiency Virus (FIV), Human Immunodeficiency Virus (HIV), Nucleocapsid Protein, Zinc Ejection}, author = {Asquith, C and Laitinen, T and Konstantinova, L and Tizzard, G and Poso, A and Rakitin, O and Hofmann-Lehmann, R and Hilton, ST} }