eprintid: 10084606 rev_number: 20 eprint_status: archive userid: 608 dir: disk0/10/08/46/06 datestamp: 2019-10-30 11:33:39 lastmod: 2021-09-19 23:14:50 status_changed: 2019-10-30 11:33:39 type: article metadata_visibility: show creators_name: Cornford, JH creators_name: Mercier, MS creators_name: Leite, M creators_name: Magloire, V creators_name: Häusser, M creators_name: Kullmann, DM title: Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies ispublished: inpress divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F81 divisions: C10 divisions: D17 divisions: G95 note: © 2019, Cornford et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). abstract: Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment, action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells is well established. In contrast, the functional significance of PV+ cell NMDA receptors (NMDARs), which generate relatively slow postsynaptic currents, is unclear. Underlining their importance, several studies implicate PV+ cell NMDAR disruption in impaired network function and circuit pathologies. Here, we show that dendritic NMDARs underlie supralinear integration of feedback excitation from local pyramidal neurons onto mouse CA1 PV+ cells. Furthermore, by incorporating NMDARs at feedback connections onto PV+ cells in spiking networks, we show that these receptors enable cooperative recruitment of PV+ interneurons, strengthening and stabilising principal cell assemblies. Failure of this phenomenon provides a parsimonious explanation for cognitive and sensory gating deficits in pathologies with impaired PV+ NMDAR signalling. date: 2019-10-28 date_type: published publisher: eLife Sciences Publications, Ltd official_url: https://doi.org/10.7554/elife.49872 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1712571 doi: 10.7554/elife.49872 language_elements: English lyricists_name: Hausser, Michael lyricists_name: Kullmann, Dimitri lyricists_name: Leite, Marco lyricists_name: Magloire, Vincent lyricists_name: Mercier, Marion lyricists_id: MHAUS91 lyricists_id: DMKUL63 lyricists_id: LEITE07 lyricists_id: VMAGL52 lyricists_id: MSMER43 actors_name: Kalinowski, Damian actors_id: DKALI47 actors_role: owner full_text_status: public publication: eLife volume: 8 issn: 2050-084X citation: Cornford, JH; Mercier, MS; Leite, M; Magloire, V; Häusser, M; Kullmann, DM; (2019) Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies. eLife , 8 10.7554/elife.49872 <https://doi.org/10.7554/elife.49872>. (In press). Green open access document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10084606/1/Kullmann_Dendritic%20NMDA%20receptors%20in%20parvalbumin%20neurons%20enable%20strong%20and%20stable%20neuronal%20assemblies_AAM.pdf