@article{discovery10085485,
          volume = {8},
            year = {2019},
         journal = {eLife},
       publisher = {ELIFE SCIENCES PUBLICATIONS LTD},
           month = {March},
            note = {This article is distributed under
the terms of the Creative
Commons Attribution License,
which permits unrestricted use
and redistribution provided that
the original author and source are
credited.
https://creativecommons.org/licenses/by/4.0/},
           title = {Dynamic control of hippocampal spatial coding resolution by local visual cues},
            issn = {2050-084X},
          author = {Bourboulou, R and Marti, G and Michon, F-X and El Feghaly, E and Nouguier, M and Robbe, D and Koenig, J and Epsztein, J},
        abstract = {The ability to flexibly navigate an environment relies on a hippocampal-dependent
cognitive map. External space can be internally mapped at different spatial resolutions. However,
whether hippocampal spatial coding resolution can rapidly adapt to local features of an
environment remains unclear. To explore this possibility, we recorded the firing of hippocampal
neurons in mice navigating virtual reality environments, embedding or not local visual cues (virtual
3D objects) in specific locations. Virtual objects enhanced spatial coding resolution in their vicinity
with a higher proportion of place cells, smaller place fields, increased spatial selectivity and
stability. This effect was highly dynamic upon objects manipulations. Objects also improved
temporal coding resolution through improved theta phase precession and theta timescale spike
coordination. We propose that the fast adaptation of hippocampal spatial coding resolution to
local features of an environment could be relevant for large-scale navigation.},
             url = {https://doi.org/10.7554/eLife.44487}
}