TY  - JOUR
TI  - Innovations in pediatric drug formulations and administration technologies for low resource settings
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
https://creativecommons.org/licenses/by/4.0/
N2  - © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Despite advances in regulations and initiatives to increase pediatric medicine development, there is still an unmet need for age-appropriate medicines for children. The availability of pediatric formulations is particularly lacking in resource poor areas, due to, for example, area-specific disease burden and financial constraints, as well as disconnected supply chains and fragmented healthcare systems. The paucity of authorized pediatric medicines often results in the manipulation and administration of products intended for adults, with an increased risk of mis-dosing and adverse reactions. This article provides an overview of the some of the key difficulties associated with the development of pediatric medicines in both high and low resource areas, and highlights shared and location specific challenges and opportunities. The utilization of dispersible oral dosage forms and suppositories for low and middle-income countries (LMICs) are described in addition to other platform technologies that may in the future offer opportunities for future pediatric medicine development for low resource settings.
AV  - public
IS  - 10
KW  - pediatric; drug development; formulation; global health; dispersible; suppository
VL  - 11
Y1  - 2019/10//
ID  - discovery10085805
JF  - Pharmaceutics
SN  - 1999-4923
UR  - https://doi.org/10.3390/pharmaceutics11100518
A1  - Gerrard, SE
A1  - Walsh, J
A1  - Bowers, N
A1  - Salunke, S
A1  - Hershenson, S
ER  -