TY  - JOUR
VL  - 1232
Y1  - 2020///
EP  - 9
AV  - public
A1  - Bale, G
A1  - Taylor, N
A1  - Mitra, S
A1  - Sudakou, A
A1  - de Roever, I
A1  - Meek, J
A1  - Robertson, N
A1  - Tachtsidis, I
KW  - Cerebral blood flow
KW  -  Clinical
KW  -  Hypoxic-ischaemic encephalopathy
KW  -  Near-infrared spectroscopy
KW  -  Neonatal brain injury
JF  - Oxygen Transport to Tissue XLI
SN  - 0065-2598
N1  - © The Author(s) 2020. This chapter is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
TI  - Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury
N2  - Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin - deoxygenated-haemoglobin) combined with arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes. The method is based on Fick's principle and uses HbD as a tracer; when a sudden change in SaO2 occurs, the change in HbD represents a change in tracer concentration, and thus it is possible to estimate CBF. CBF was successfully calculated with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g-1 min-1 with a range of 4 ml 100 g-1 min-1 to 60 ml 100 g-1 min-1. For infants with severe HIE (as determined by magnetic resonance spectroscopy) CBF was significantly lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth.
SP  - 3
UR  - https://doi.org/10.1007/978-3-030-34461-0_1
ID  - discovery10089030
ER  -