eprintid: 10089030
rev_number: 26
eprint_status: archive
userid: 608
dir: disk0/10/08/90/30
datestamp: 2020-01-08 16:49:17
lastmod: 2021-12-08 23:40:05
status_changed: 2020-01-08 16:49:17
type: article
metadata_visibility: show
creators_name: Bale, G
creators_name: Taylor, N
creators_name: Mitra, S
creators_name: Sudakou, A
creators_name: de Roever, I
creators_name: Meek, J
creators_name: Robertson, N
creators_name: Tachtsidis, I
title: Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury
ispublished: pub
divisions: UCL
divisions: B02
divisions: D11
divisions: G14
divisions: B04
divisions: C05
divisions: F42
keywords: Cerebral blood flow, Clinical, Hypoxic-ischaemic encephalopathy, Near-infrared spectroscopy, Neonatal brain injury
note: © The Author(s) 2020. This chapter is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
abstract: Neonates with hypoxic-ischaemic (HI) brain injury were monitored using a broadband near-infrared spectroscopy (NIRS) system in the neonatal intensive care unit. The aim of this work is to use the NIRS cerebral oxygenation data (HbD = oxygenated-haemoglobin - deoxygenated-haemoglobin) combined with arterial saturation (SaO2) from pulse oximetry to calculate cerebral blood flow (CBF) based on the oxygen swing method, during spontaneous desaturation episodes. The method is based on Fick's principle and uses HbD as a tracer; when a sudden change in SaO2 occurs, the change in HbD represents a change in tracer concentration, and thus it is possible to estimate CBF. CBF was successfully calculated with broadband NIRS in 11 HIE infants (3 with severe injury) for 70 oxygenation events on the day of birth. The average CBF was 18.0 ± 12.7 ml 100 g-1 min-1 with a range of 4 ml 100 g-1 min-1 to 60 ml 100 g-1 min-1. For infants with severe HIE (as determined by magnetic resonance spectroscopy) CBF was significantly lower (p = 0.038, d = 1.35) than those with moderate HIE on the day of birth.
date: 2020
date_type: published
official_url: https://doi.org/10.1007/978-3-030-34461-0_1
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1737495
doi: 10.1007/978-3-030-34461-0_1
lyricists_name: Bale, Gemma
lyricists_name: Meek, Judith
lyricists_name: Mitra, Subhabrata
lyricists_name: Robertson, Nicola
lyricists_name: Tachtsidis, Ilias
lyricists_id: GMBAL14
lyricists_id: JHMEE48
lyricists_id: MITRA07
lyricists_id: NROBE79
lyricists_id: ITACH19
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Oxygen Transport to Tissue XLI
volume: 1232
pagerange: 3-9
event_location: United States
issn: 0065-2598
citation:        Bale, G;    Taylor, N;    Mitra, S;    Sudakou, A;    de Roever, I;    Meek, J;    Robertson, N;           Bale, G;  Taylor, N;  Mitra, S;  Sudakou, A;  de Roever, I;  Meek, J;  Robertson, N;  Tachtsidis, I;   - view fewer <#>    (2020)    Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury.                   Oxygen Transport to Tissue XLI , 1232    pp. 3-9.    10.1007/978-3-030-34461-0_1 <https://doi.org/10.1007/978-3-030-34461-0_1>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10089030/1/Bale2020_Chapter_Near-InfraredSpectroscopyMeasu.pdf