<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/title> "Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/abstract> "Background: Recent clinical, experimental and modeling studies link oscillations of\r\nventricular repolarization in the low frequency (LF) (approx. 0.1 Hz) to arrhythmogenesis.\r\nSympathetic provocation has been shown to enhance both LF oscillations of action\r\npotential duration (APD) and beat-to-beat variability (BVR) in humans. We hypothesized\r\nthat beta-adrenergic blockade would reduce LF oscillations of APD and BVR of APD in\r\nhumans and that the two processes might be linked.\r\nMethods and Results: Twelve patients with normal ventricles were studied during\r\nroutine electrophysiological procedures. Activation-recovery intervals (ARI) as a\r\nconventional surrogate for APD were recorded from 10 left and 10 right ventricular\r\nendocardial sites before and after acute beta-adrenergic adrenergic blockade. Cycle\r\nlength was maintained constant with right ventricular pacing. Oscillatory behavior of\r\nARI was quantified by spectral analysis and BVR as the short-term variability. Betaadrenergic\r\nblockade reduced LF ARI oscillations (8.6 ± 4.5 ms2 vs. 5.5 ± 3.5 ms2,\r\np = 0.027). A significant correlation was present between the initial control values and\r\nreduction seen following beta-adrenergic blockade in LF ARI (rs = 0.62, p = 0.037)\r\nsuch that when initial values are high the effect is greater. A similar relationship was also\r\nseen in the beat-to beat variability of ARI (rs = 0.74, p = 0.008). There was a significant\r\ncorrelation between the beta-adrenergic blockade induced reduction in LF power of\r\nARI and the witnessed reduction of beat-to-beat variability of ARI (rs = 0.74, p = 0.01).\r\nThese clinical results accord with recent computational modeling studies which provide\r\nmechanistic insight into the interactions of LF oscillations and beat-to-beat variability of\r\nAPD at the cellular level. Conclusion: Beta-adrenergic blockade reduces LF oscillatory behavior of APD (ARI) in\r\nhumans in vivo. Our results support the importance of LF oscillations in modulating the\r\nresponse of BVR to beta-adrenergic blockers, suggesting that LF oscillations may play\r\nrole in modulating beta-adrenergic mechanisms underlying BVR."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/date> "2020-01-22" . <https://discovery-pp.ucl.ac.uk/id/document/1054962> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/volume> "10" . <https://discovery-pp.ucl.ac.uk/id/org/ext-8b71f89f689c576aaf4c01416029f6c1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery-pp.ucl.ac.uk/id/org/ext-8b71f89f689c576aaf4c01416029f6c1> <http://xmlns.com/foaf/0.1/name> "FRONTIERS MEDIA SA"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/publisher> <https://discovery-pp.ucl.ac.uk/id/org/ext-8b71f89f689c576aaf4c01416029f6c1> . <https://discovery-pp.ucl.ac.uk/id/publication/ext-4f5ba3aba67f7e70576fd06eae43ec16> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery-pp.ucl.ac.uk/id/publication/ext-4f5ba3aba67f7e70576fd06eae43ec16> <http://xmlns.com/foaf/0.1/name> "Frontiers in Physiology"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/isPartOf> <https://discovery-pp.ucl.ac.uk/id/publication/ext-4f5ba3aba67f7e70576fd06eae43ec16> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-da3ccc417bf9f838990376ea6ffc3cfe> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery-pp.ucl.ac.uk/id/person/ext-da3ccc417bf9f838990376ea6ffc3cfe> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-60c971a47343a374f1ef6b99e0874a22> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery-pp.ucl.ac.uk/id/person/ext-60c971a47343a374f1ef6b99e0874a22> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-e16a365099d280608aca37103cca942f> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery-pp.ucl.ac.uk/id/person/ext-e16a365099d280608aca37103cca942f> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-6250d6c142917b51e3c4a7c815a83c7e> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery-pp.ucl.ac.uk/id/person/ext-6250d6c142917b51e3c4a7c815a83c7e> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-e10023e4d898ce0f42eeedb981e0fe28> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery-pp.ucl.ac.uk/id/person/ext-e10023e4d898ce0f42eeedb981e0fe28> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-07dd6a0dd049fff73b506228c726ccea> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery-pp.ucl.ac.uk/id/person/ext-07dd6a0dd049fff73b506228c726ccea> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-ac9a7d3435e19da9984e7c2bf52f4b5a> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery-pp.ucl.ac.uk/id/person/ext-ac9a7d3435e19da9984e7c2bf52f4b5a> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-0fe89f643d9672508ba4a3bfb0a29bea> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery-pp.ucl.ac.uk/id/person/ext-0fe89f643d9672508ba4a3bfb0a29bea> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-028d0e49f76b20c0af5e4386ae941b8e> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery-pp.ucl.ac.uk/id/person/ext-028d0e49f76b20c0af5e4386ae941b8e> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-56c0393d03625863f59e024650dad263> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery-pp.ucl.ac.uk/id/person/ext-56c0393d03625863f59e024650dad263> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-a41a46fa744edb549bbab159d0adc23f> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery-pp.ucl.ac.uk/id/person/ext-a41a46fa744edb549bbab159d0adc23f> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-c7eff1378e600254f4f226e7a31e397d> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery-pp.ucl.ac.uk/id/person/ext-c7eff1378e600254f4f226e7a31e397d> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-9498401cffda565c9e31dd411f5b0ade> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery-pp.ucl.ac.uk/id/person/ext-9498401cffda565c9e31dd411f5b0ade> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-eb245fb424fef7783fac894bb8977f28> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery-pp.ucl.ac.uk/id/person/ext-eb245fb424fef7783fac894bb8977f28> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-62ffefbfba99e30f2bf5a4d3f1729c27> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> . <https://discovery-pp.ucl.ac.uk/id/eprint/10091767#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery-pp.ucl.ac.uk/id/person/ext-62ffefbfba99e30f2bf5a4d3f1729c27> . <https://discovery-pp.ucl.ac.uk/id/person/ext-0fe89f643d9672508ba4a3bfb0a29bea> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-0fe89f643d9672508ba4a3bfb0a29bea> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-0fe89f643d9672508ba4a3bfb0a29bea> <http://xmlns.com/foaf/0.1/familyName> "Orini"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-0fe89f643d9672508ba4a3bfb0a29bea> <http://xmlns.com/foaf/0.1/name> "M Orini"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-62ffefbfba99e30f2bf5a4d3f1729c27> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-62ffefbfba99e30f2bf5a4d3f1729c27> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-62ffefbfba99e30f2bf5a4d3f1729c27> <http://xmlns.com/foaf/0.1/familyName> "Taggart"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-62ffefbfba99e30f2bf5a4d3f1729c27> <http://xmlns.com/foaf/0.1/name> "P Taggart"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e10023e4d898ce0f42eeedb981e0fe28> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e10023e4d898ce0f42eeedb981e0fe28> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e10023e4d898ce0f42eeedb981e0fe28> <http://xmlns.com/foaf/0.1/familyName> "Fernandez-Bes"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e10023e4d898ce0f42eeedb981e0fe28> <http://xmlns.com/foaf/0.1/name> "J Fernandez-Bes"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-9498401cffda565c9e31dd411f5b0ade> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-9498401cffda565c9e31dd411f5b0ade> <http://xmlns.com/foaf/0.1/givenName> "CA"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-9498401cffda565c9e31dd411f5b0ade> <http://xmlns.com/foaf/0.1/familyName> "Rinaldi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-9498401cffda565c9e31dd411f5b0ade> <http://xmlns.com/foaf/0.1/name> "CA Rinaldi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-eb245fb424fef7783fac894bb8977f28> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-eb245fb424fef7783fac894bb8977f28> <http://xmlns.com/foaf/0.1/givenName> "JS"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-eb245fb424fef7783fac894bb8977f28> <http://xmlns.com/foaf/0.1/familyName> "Gill"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-eb245fb424fef7783fac894bb8977f28> <http://xmlns.com/foaf/0.1/name> "JS Gill"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-da3ccc417bf9f838990376ea6ffc3cfe> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-da3ccc417bf9f838990376ea6ffc3cfe> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-da3ccc417bf9f838990376ea6ffc3cfe> <http://xmlns.com/foaf/0.1/familyName> "Van Duijvenboden"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-da3ccc417bf9f838990376ea6ffc3cfe> <http://xmlns.com/foaf/0.1/name> "S Van Duijvenboden"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e16a365099d280608aca37103cca942f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e16a365099d280608aca37103cca942f> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e16a365099d280608aca37103cca942f> <http://xmlns.com/foaf/0.1/familyName> "Pueyo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-e16a365099d280608aca37103cca942f> <http://xmlns.com/foaf/0.1/name> "E Pueyo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-07dd6a0dd049fff73b506228c726ccea> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-07dd6a0dd049fff73b506228c726ccea> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-07dd6a0dd049fff73b506228c726ccea> <http://xmlns.com/foaf/0.1/familyName> "Sidhu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-07dd6a0dd049fff73b506228c726ccea> <http://xmlns.com/foaf/0.1/name> "B Sidhu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-56c0393d03625863f59e024650dad263> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery-pp.ucl.ac.uk/id/person/ext-56c0393d03625863f59e024650dad263> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery-pp.ucl.ac.uk/id/person/ext-56c0393d03625863f59e024650dad263> <http://xmlns.com/foaf/0.1/familyName> "Hanson"^^<http://www.w3.org/2001/XMLSchema#string> . 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