eprintid: 10098785
rev_number: 8
eprint_status: archive
userid: 695
dir: disk0/10/09/87/85
datestamp: 2020-05-27 17:21:01
lastmod: 2020-05-27 17:21:01
status_changed: 2020-05-27 17:21:01
type: thesis
metadata_visibility: show
creators_name: Elwell, Clare Elizabeth
title: Measurement and data analysis techniques for the investigation of adult cerebral haemodynamics using near infrared spectroscopy
ispublished: unpub
keywords: Applied sciences
note: Thesis digitised by ProQuest.
abstract: The technique of near infrared spectroscopy (NIRS) has been widely used for several years as a monitor of tissue oxygenation in intact organs. The aim of the work described in this thesis was to investigate the applicability of the technique in performing quantitative measurements of cerebral haemodynamics in the adult. The physiological background to the project is presented in the first chapter and describes the role of the cerebral circulation and the current methods employed for the measurement of cerebral blood flow (CBF) and cerebral blood volume (CBV) in adults. The physical principles behind the technique of NIRS are then described in the second chapter, with particular emphasis on the behaviour of light within a highly scattering media such as biological tissue. Chapter Three completes the technical background with details of the current instrumentation used for NIRS measurements. Physiological measurements have been performed on healthy adult volunteers for the measurement of CBF, CBV and mean cerebral saturation (SmcO2). These studies are described in the fourth and fifth chapters together with a detailed interpretation of the results. The relatively high blood flow of the adult brain imposes limits on the hardware and software requirements for the measurement of CBF and the resulting methodological problems and sources of error are also discussed. A description of the measurement of changes in cerebral haemodynamics during inspiration and expiration is given to demonstrate the use of the technique in monitoring rapid changes in cerebral oxygenation. Chapter Six describes the development and testing of a novel analysis method for the calculation of CBF. It is hoped that this analytical method, which is based upon the measurement of cerebral vascular transit time, will improve the clinical usefulness of the technique.
date: 1995
oa_status: green
full_text_type: other
thesis_class: doctoral_open
thesis_award: Ph.D
language: eng
thesis_view: UCL_Thesis
primo: open
primo_central: open_green
verified: verified_manual
full_text_status: public
pages: 187
institution: UCL (University College London)
department: Department of Medical Physics and Bioengineering
thesis_type: Doctoral
citation:        Elwell, Clare Elizabeth;      (1995)    Measurement and data analysis techniques for the investigation of adult cerebral haemodynamics using near infrared spectroscopy.                   Doctoral thesis  (Ph.D), UCL (University College London).     Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10098785/1/10017314.pdf