%0 Journal Article
%A Katagiri, Y
%A Torii, R
%A Takahashi, K
%A Tenekecioglu, E
%A Asano, T
%A Chichareon, P
%A Tomaniak, M
%A Piek, JJ
%A Wykrzykowska, JJ
%A Bullett, N
%A Ahmed, N
%A Al-Lamee, K
%A Al-Lamee, R
%A Leclerc, G
%A Kitslaar, P
%A Dijkstra, J
%A Reiber, JHC
%A Poon, EKW
%A Bourantas, C
%A Gijsen, F
%A Serruys, PW
%A Onuma, Y
%D 2020
%F discovery:10116772
%I EUROPA EDITION
%J EuroIntervention
%N 2
%P e141-e146
%T Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb)
%U https://discovery-pp.ucl.ac.uk/id/eprint/10116772/
%V 16
%X Aims: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries.    Methods and results: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314).    Conclusions: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.