%0 Journal Article %A Katagiri, Y %A Torii, R %A Takahashi, K %A Tenekecioglu, E %A Asano, T %A Chichareon, P %A Tomaniak, M %A Piek, JJ %A Wykrzykowska, JJ %A Bullett, N %A Ahmed, N %A Al-Lamee, K %A Al-Lamee, R %A Leclerc, G %A Kitslaar, P %A Dijkstra, J %A Reiber, JHC %A Poon, EKW %A Bourantas, C %A Gijsen, F %A Serruys, PW %A Onuma, Y %D 2020 %F discovery:10116772 %I EUROPA EDITION %J EuroIntervention %N 2 %P e141-e146 %T Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb) %U https://discovery-pp.ucl.ac.uk/id/eprint/10116772/ %V 16 %X Aims: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries. Methods and results: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314). Conclusions: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES. %Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.