eprintid: 10117137
rev_number: 21
eprint_status: archive
userid: 608
dir: disk0/10/11/71/37
datestamp: 2020-12-14 11:04:53
lastmod: 2022-01-20 23:37:14
status_changed: 2020-12-14 11:04:53
type: article
metadata_visibility: show
creators_name: Erro, R
creators_name: Antelmi, E
creators_name: Bhatia, KP
creators_name: Latorre, A
creators_name: Tinazzi, M
creators_name: Berardelli, A
creators_name: Rothwell, JC
creators_name: Rocchi, L
title: Reversal of Temporal Discrimination in Cervical Dystonia after Low-Frequency Sensory Stimulation
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
divisions: F75
keywords: inhibition, temporal discrimination, pathophysiology, plasticity, somatosensory
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: BACKGROUND: Somatosensory temporal discrimination is abnormal in dystonia and reflects reduced somatosensory inhibition. In healthy individuals, both the latter are enhanced by high‐frequency repetitive somatosensory stimulation, whereas opposite effects are observed in patients with cervical dystonia. OBJECTIVES: We tested whether low‐frequency repetitive sensory stimulation, which in healthy individuals worsens discrimination, might have the opposite effect in patients with cervical dystonia at the physiological level and, in turn, improve their perceptual performance. METHODS: Somatosensory temporal discrimination and several electrophysiological measures of sensorimotor inhibition were collected before and after 45 minutes of low‐frequency repetitive sensory stimulation. RESULTS: As predicted, and opposite to what happened in controls, low‐frequency repetitive sensory stimulation in patients enhanced sensorimotor inhibition and normalized somatosensory temporal discrimination. CONCLUSIONS: Patients with cervical dystonia have an abnormal response to repetitive sensory stimulation, which we hypothesize is attributed to abnormally sensitive homeostatic mechanisms of inhibitory circuitry in both sensory and motor systems.
date: 2020-11-07
date_type: published
publisher: WILEY
official_url: https://doi.org/10.1002/mds.28369
full_text_type: other
language: eng
verified: verified_manual
elements_id: 1828479
doi: 10.1002/mds.28369
lyricists_name: Bhatia, Kailash
lyricists_name: Latorre, Anna
lyricists_name: Rocchi, Lorenzo
lyricists_name: Rothwell, John
lyricists_id: KPBHA96
lyricists_id: ALATO85
lyricists_id: LROCC06
lyricists_id: JCROT52
actors_name: Bhatia, Kailash
actors_name: Taib, Linda
actors_id: KPBHA96
actors_id: LTAIB41
actors_role: owner
actors_role: impersonator
full_text_status: restricted
publication: Movement Disorders
pages: 7
citation:        Erro, R;    Antelmi, E;    Bhatia, KP;    Latorre, A;    Tinazzi, M;    Berardelli, A;    Rothwell, JC;           Erro, R;  Antelmi, E;  Bhatia, KP;  Latorre, A;  Tinazzi, M;  Berardelli, A;  Rothwell, JC;  Rocchi, L;   - view fewer <#>    (2020)    Reversal of Temporal Discrimination in Cervical Dystonia after Low-Frequency Sensory Stimulation.                   Movement Disorders        10.1002/mds.28369 <https://doi.org/10.1002/mds.28369>.    (In press).   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10117137/3/Bhatia_Reversal%20of%20Temporal%20Discrimination%20in%20Cervical%20Dystonia%20after%20Low-Frequency%20Sensory%20Stimulation_AAM.pdf