eprintid: 10126373
rev_number: 21
eprint_status: archive
userid: 608
dir: disk0/10/12/63/73
datestamp: 2021-04-22 13:24:31
lastmod: 2022-01-07 23:45:57
status_changed: 2021-04-22 13:24:31
type: article
metadata_visibility: show
creators_name: Kohli, N
creators_name: Sharma, V
creators_name: Orera, A
creators_name: Sawadkar, P
creators_name: Owji, N
creators_name: Frost, OG
creators_name: Bailey, RJ
creators_name: Snow, M
creators_name: Knowles, JC
creators_name: Blunn, GW
creators_name: García-Gareta, E
title: Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C10
divisions: D21
divisions: H10
divisions: D13
divisions: G22
keywords: Bone tissue engineering, angiogenic, osteogenic, fibrin, calcium phosphate
note: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
abstract: Due to the limitations of bone autografts, we aimed to develop new composite biomaterials with pro-angiogenic and osteogenic properties to be used as scaffolds in bone tissue engineering applications. We used a porous, cross-linked and slowly biodegradable fibrin/alginate scaffold originally developed in our laboratory for wound healing, throughout which deposits of calcium phosphate (CaP) were evenly incorporated using an established biomimetic method. Material characterisation revealed the porous nature and confirmed the deposition of CaP precursor phases throughout the scaffolds. MC3T3-E1 cells adhered to the scaffolds, proliferated, migrated and differentiated down the osteogenic pathway during the culture period. Chick chorioallantoic membrane (CAM) assay results showed that the scaffolds were pro-angiogenic and biocompatible. The work presented here gave useful insights into the potential of these pro-angiogenic and osteogenic scaffolds for bone tissue engineering and merits further research in a pre-clinical model prior to its clinical translation.
date: 2021-04-06
date_type: published
publisher: SAGE Publications
official_url: https://doi.org/10.1177%2F20417314211005610
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1858583
doi: 10.1177/20417314211005610
lyricists_name: Garcia, Elena
lyricists_name: Knowles, Jonathan
lyricists_name: Owji, Nazanin
lyricists_id: EGARC71
lyricists_id: JCKNO52
lyricists_id: NOWJI02
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Journal of Tissue Engineering
volume: 12
citation:        Kohli, N;    Sharma, V;    Orera, A;    Sawadkar, P;    Owji, N;    Frost, OG;    Bailey, RJ;                 ... García-Gareta, E; + view all <#>        Kohli, N;  Sharma, V;  Orera, A;  Sawadkar, P;  Owji, N;  Frost, OG;  Bailey, RJ;  Snow, M;  Knowles, JC;  Blunn, GW;  García-Gareta, E;   - view fewer <#>    (2021)    Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering.                   Journal of Tissue Engineering , 12       10.1177/20417314211005610 <https://doi.org/10.1177/20417314211005610>.    (In press).    Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10126373/1/20417314211005610.pdf