eprintid: 10127153
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/12/71/53
datestamp: 2021-05-10 13:31:18
lastmod: 2021-11-30 22:54:54
status_changed: 2021-05-10 13:31:18
type: article
metadata_visibility: show
creators_name: Vrablik, M
creators_name: Dlouha, D
creators_name: Todorovova, V
creators_name: Stefler, D
creators_name: Hubacek, JA
title: Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?
ispublished: pub
divisions: UCL
divisions: B02
divisions: D12
divisions: G19
keywords: cardiovascular disease; gene; interaction; polymorphism; gene score; epigenetic
note: This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this disease remains a major cause of mortality and morbidity. Recent progress over the last two decades in the field of molecular genetics, especially with new tools such as genome-wide association studies, has helped to identify new genes and their variants, which can be used for calculations of risk, prediction of treatment efficacy, or detection of subjects prone to drug side effects. Although the use of genetic risk scores further improves CVD prediction, the significance is not unambiguous, and some subjects at risk remain undetected. Further research directions should focus on the “second level” of genetic information, namely, regulatory molecules (miRNAs) and epigenetic changes, predominantly DNA methylation and gene-environment interactions.
date: 2021-04-02
official_url: https://doi.org/10.3390/ijms22084182
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1862382
doi: 10.3390/ijms22084182
lyricists_name: Stefler, Denes
lyricists_id: DSTEF71
actors_name: Stefler, Denes
actors_id: DSTEF71
actors_role: owner
full_text_status: public
publication: International Journal of Molecular Sciences
volume: 22
number: 8
article_number: 4182
citation:        Vrablik, M;    Dlouha, D;    Todorovova, V;    Stefler, D;    Hubacek, JA;      (2021)    Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?                   International Journal of Molecular Sciences , 22  (8)    , Article 4182.  10.3390/ijms22084182 <https://doi.org/10.3390/ijms22084182>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10127153/1/ijms-22-04182-v2.pdf