<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624> .
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<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/title> "The non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/abstract> "Astrocytic GLT-1 is the main glutamate transporter involved in glutamate buffering in the brain, pivotal for glutamate removal at excitatory synapses to terminate neurotransmission and for preventing excitotoxicity. We show here that the surface expression and function of GLT-1 can be rapidly modulated through the interaction of its N-terminus with the nonadrenergic imidazoline-1 receptor protein, Nischarin. The phox domain of Nischarin is critical for interaction and internalization of surface GLT-1. Using live super-resolution imaging, we found that glutamate accelerated Nischarin-GLT-1 internalization into endosomal structures. The surface GLT-1 level increased in Nischarin knockout astrocytes, and this correlated with a significant increase in transporter uptake current. In addition, Nischarin knockout in astrocytes is neuroprotective against glutamate excitotoxicity. These data provide new molecular insights into regulation of GLT-1 surface level and function and suggest new drug targets for the treatment of neurological disorders."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/date> "2022-04-15" .
<https://discovery-pp.ucl.ac.uk/id/document/1464339> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/volume> "25" .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/issue> "4" .
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<https://discovery-pp.ucl.ac.uk/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1> <http://xmlns.com/foaf/0.1/name> "Elsevier BV"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery-pp.ucl.ac.uk/id/publication/ext-c1db315fdbc48f1c5b4aac4e90062c92> <http://xmlns.com/foaf/0.1/name> "iScience"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/isPartOf> <https://discovery-pp.ucl.ac.uk/id/publication/ext-c1db315fdbc48f1c5b4aac4e90062c92> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-0b4bade85ae369196a57c6590fc106c8> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery-pp.ucl.ac.uk/id/person/ext-0b4bade85ae369196a57c6590fc106c8> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-812d756d35ec9963fd8a9da65be1f6f4> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery-pp.ucl.ac.uk/id/person/ext-812d756d35ec9963fd8a9da65be1f6f4> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-6a1f27e88dc3e2974b73a13bc384da83> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery-pp.ucl.ac.uk/id/person/ext-6a1f27e88dc3e2974b73a13bc384da83> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-a570d16f7e2e9150275c84c0407d1429> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery-pp.ucl.ac.uk/id/person/ext-a570d16f7e2e9150275c84c0407d1429> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-5164530da6beb6bf25d87d74192c86ac> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery-pp.ucl.ac.uk/id/person/ext-5164530da6beb6bf25d87d74192c86ac> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-63bce771ed2d5ad0d474440f3b895029> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery-pp.ucl.ac.uk/id/person/ext-63bce771ed2d5ad0d474440f3b895029> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-1d7446b5a90e84f18b4828e1ba54accb> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery-pp.ucl.ac.uk/id/person/ext-1d7446b5a90e84f18b4828e1ba54accb> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-b7d87ab846ebe816e2c644af035d6357> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery-pp.ucl.ac.uk/id/person/ext-b7d87ab846ebe816e2c644af035d6357> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-42c72991226884c76a9b68014a7293f8> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery-pp.ucl.ac.uk/id/person/ext-42c72991226884c76a9b68014a7293f8> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-812d756d35ec9963fd8a9da65be1f6f4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-812d756d35ec9963fd8a9da65be1f6f4> <http://xmlns.com/foaf/0.1/givenName> "Narges"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-812d756d35ec9963fd8a9da65be1f6f4> <http://xmlns.com/foaf/0.1/familyName> "Bazargani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-812d756d35ec9963fd8a9da65be1f6f4> <http://xmlns.com/foaf/0.1/name> "Narges Bazargani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-6a1f27e88dc3e2974b73a13bc384da83> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-6a1f27e88dc3e2974b73a13bc384da83> <http://xmlns.com/foaf/0.1/givenName> "James"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-6a1f27e88dc3e2974b73a13bc384da83> <http://xmlns.com/foaf/0.1/familyName> "Drew"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-6a1f27e88dc3e2974b73a13bc384da83> <http://xmlns.com/foaf/0.1/name> "James Drew"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-42c72991226884c76a9b68014a7293f8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-42c72991226884c76a9b68014a7293f8> <http://xmlns.com/foaf/0.1/givenName> "Josef T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-42c72991226884c76a9b68014a7293f8> <http://xmlns.com/foaf/0.1/familyName> "Kittler"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-42c72991226884c76a9b68014a7293f8> <http://xmlns.com/foaf/0.1/name> "Josef T Kittler"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a570d16f7e2e9150275c84c0407d1429> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a570d16f7e2e9150275c84c0407d1429> <http://xmlns.com/foaf/0.1/givenName> "Jack"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a570d16f7e2e9150275c84c0407d1429> <http://xmlns.com/foaf/0.1/familyName> "Howden"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a570d16f7e2e9150275c84c0407d1429> <http://xmlns.com/foaf/0.1/name> "Jack Howden"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-63bce771ed2d5ad0d474440f3b895029> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-63bce771ed2d5ad0d474440f3b895029> <http://xmlns.com/foaf/0.1/givenName> "Sana"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-63bce771ed2d5ad0d474440f3b895029> <http://xmlns.com/foaf/0.1/familyName> "Al Awabdh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-63bce771ed2d5ad0d474440f3b895029> <http://xmlns.com/foaf/0.1/name> "Sana Al Awabdh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-1d7446b5a90e84f18b4828e1ba54accb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-1d7446b5a90e84f18b4828e1ba54accb> <http://xmlns.com/foaf/0.1/givenName> "Hélène"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-1d7446b5a90e84f18b4828e1ba54accb> <http://xmlns.com/foaf/0.1/familyName> "Marie"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-1d7446b5a90e84f18b4828e1ba54accb> <http://xmlns.com/foaf/0.1/name> "Hélène Marie"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-0b4bade85ae369196a57c6590fc106c8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-0b4bade85ae369196a57c6590fc106c8> <http://xmlns.com/foaf/0.1/givenName> "Swati"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-0b4bade85ae369196a57c6590fc106c8> <http://xmlns.com/foaf/0.1/familyName> "Gupta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-0b4bade85ae369196a57c6590fc106c8> <http://xmlns.com/foaf/0.1/name> "Swati Gupta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5164530da6beb6bf25d87d74192c86ac> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5164530da6beb6bf25d87d74192c86ac> <http://xmlns.com/foaf/0.1/givenName> "Souvik"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5164530da6beb6bf25d87d74192c86ac> <http://xmlns.com/foaf/0.1/familyName> "Modi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5164530da6beb6bf25d87d74192c86ac> <http://xmlns.com/foaf/0.1/name> "Souvik Modi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b7d87ab846ebe816e2c644af035d6357> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b7d87ab846ebe816e2c644af035d6357> <http://xmlns.com/foaf/0.1/givenName> "David"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b7d87ab846ebe816e2c644af035d6357> <http://xmlns.com/foaf/0.1/familyName> "Attwell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b7d87ab846ebe816e2c644af035d6357> <http://xmlns.com/foaf/0.1/name> "David Attwell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10146624> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
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