TY - JOUR SP - 5872 N1 - © The Royal Society of Chemistry 2022. This article is Open Access (http://creativecommons.org/licenses/by-nc/3.0/). EP - 5883 PB - Royal Society of Chemistry (RSC) VL - 13 AV - public A1 - Bolt, Robert RA A1 - Leitch, Jamie A A1 - Jones, Andrew C A1 - Nicholson, William I A1 - Browne, Duncan L ID - discovery10148172 UR - https://doi.org/10.1039/D2SC01538B JF - Chemical Society Reviews N2 - Rapid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique opportunities which have been offered in solvent-free - or highly solvent-minimised - reaction systems. Nevertheless, despite elegant advances in ball-milling technology, limitations in scale-up still remain. This tutorial review covers the first reports into the translation from "batch-mode" ball-milling to "flow-mode" reactive extrusion, using twin-screw extrusion. TI - Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis Y1 - 2022/05/28/ ER -