%D 2022 %T Electrochemical Deconstructive Functionalization of Cycloalkanols via Alkoxy Radicals Enabled by Proton-Coupled Electron Transfer %N 21 %O © 2022 The Authors. Published by American Chemical Society. Original content in this article is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). %X Herein, we report a new electrochemical method for alkoxy radical generation from alcohols using a proton-coupled electron transfer (PCET) approach, showcased via the deconstructive functionalization of cycloalkanols. The electrochemical method is applicable across a diverse array of substituted cycloalkanols, accessing a broad range of synthetically useful distally functionalized ketones. The orthogonal derivatization of the products has been demonstrated through chemoselective transformations, and the electrochemical process has been performed on a gram scale in continuous single-pass flow. %A Mishra Deepak Hareram %A Albara AMA El Gehani %A James Harnedy %A Alex C Seastram %A Andrew C Jones %A Matthew Burns %A Thomas Wirth %A Duncan L Browne %A Louis C Morrill %V 24 %P 3890-3895 %C United States %L discovery10149766 %I American Chemical Society (ACS) %J Organic Letters