TY  - JOUR
TI  - A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study
AV  - public
KW  - PC-COS project steering committee
ID  - discovery10151738
UR  - https://doi.org/10.1016/S2213-2600(22)00169-2
JF  - The Lancet Respiratory Medicine
N2  - Health consequences that persist beyond the acute infection phase of COVID-19, termed post-COVID-19 condition (also commonly known as long COVID), vary widely and represent a growing global health challenge. Research on post-COVID-19 condition is expanding but, at present, no agreement exists on the health outcomes that should be measured in people living with the condition. To address this gap, we conducted an international consensus study, which included a comprehensive literature review and classification of outcomes for post-COVID-19 condition that informed a two-round online modified Delphi process followed by an online consensus meeting to finalise the core outcome set (COS). 1535 participants from 71 countries were involved, with 1148 individuals participating in both Delphi rounds. Eleven outcomes achieved consensus for inclusion in the final COS: fatigue; pain; post-exertion symptoms; work or occupational and study changes; survival; and functioning, symptoms, and conditions for each of cardiovascular, respiratory, nervous system, cognitive, mental health, and physical outcomes. Recovery was included a priori because it was a relevant outcome that was part of a previously published COS on COVID-19. The next step in this COS development exercise will be to establish the instruments that are most appropriate to measure these core outcomes. This international consensus-based COS should provide a framework for standardised assessment of adults with post-COVID-19 condition, aimed at facilitating clinical care and research worldwide.
PB  - Elsevier
A1  - Munblit, Daniel
A1  - Nicholson, Timothy
A1  - Akrami, Athena
A1  - Apfelbacher, Christian
A1  - Chen, Jessica
A1  - De Groote, Wouter
A1  - Diaz, Janet V
A1  - Gorst, Sarah L
A1  - Harman, Nicola
A1  - Kokorina, Alisa
A1  - Olliaro, Piero
A1  - Parr, Callum
A1  - Preller, Jacobus
A1  - Schiess, Nicoline
A1  - Schmitt, Jochen
A1  - Seylanova, Nina
A1  - Simpson, Frances
A1  - Tong, Allison
A1  - Needham, Dale M
A1  - Williamson, Paula R
A1  - PC-COS project steering committee
IS  - 7
VL  - 10
N1  - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions.
EP  - 724
Y1  - 2022/07//
SP  - 715
ER  -