eprintid: 10161664
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/16/16/64
datestamp: 2022-12-14 12:33:44
lastmod: 2022-12-14 12:33:44
status_changed: 2022-12-14 12:33:44
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Wolstencroft, Jeanne
creators_name: Mandy, William
creators_name: Skuse, David
title: Mental health and neurodevelopment in children and adolescents with Turner syndrome
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D05
divisions: D13
divisions: F66
divisions: G25
keywords: autism, rare disorder, sex chromosome, turner syndrome, women’s health
note: © The Author(s) 2022. This article is distributed under the terms of the Creative Commons
Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/).
abstract: OBJECTIVES: Turner syndrome (TS) is a rare sex chromosome aneuploidy, with an incidence of four in 10,000 new-born girls. TS is often associated with impaired social communication skills, but the extent to which these are attributable to Autism Spectrum Disorders (ASD) is uncertain. We made standardized assessments of the mental health and associated neurodevelopmental disorders in children and adolescents with TS and report on the prevalence of concurrent conditions. METHODS: Our sample comprised 127 girls with TS, 5-19 years of age. We obtained reports of their mental health from a combination of diagnostic interview (the Development and Wellbeing Assessment (DAWBA)), from the Strengths and Difficulties Questionnaire (SDQ) and from the Social Responsiveness Scale (SRS-2). Sources of information included parents, teachers and self-reports. The prevalence of mental health disorders in this sample was compared with age/sex matched national English data from typical controls. RESULTS: Most individuals with TS (83%) had experienced significant social communication difficulties and nearly one in four (23%) met diagnostic criteria for ASD on the DAWBA. One-third (34%) had at least one mental health or neurodevelopmental condition, and those girls with an ASD were at a greater risk of a co-occurring emotional disorder and/or attention deficit hyperactivity disorder (ADHD). CONCLUSION: Children and adolescents with TS are substantially more likely to meet criteria for ASD than their typically developing peers. Our finding has clinical implications for appropriate behavioural management from preschool through to adolescence.
date: 2022-12
date_type: published
publisher: SAGE Publications
official_url: https://doi.org/10.1177/17455057221133635
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1994695
doi: 10.1177/17455057221133635
medium: Print
lyricists_name: Mandy, William
lyricists_name: Wolstencroft, Jeanne
lyricists_id: WMAND51
lyricists_id: JWOLS89
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Women's Health
volume: 18
pagerange: 1-8
event_location: United States
citation:        Wolstencroft, Jeanne;    Mandy, William;    Skuse, David;      (2022)    Mental health and neurodevelopment in children and adolescents with Turner syndrome.                   Women's Health , 18    pp. 1-8.    10.1177/17455057221133635 <https://doi.org/10.1177/17455057221133635>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10161664/1/17455057221133635.pdf