<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/title> "Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/abstract> "Background: Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) disease spectrum, causing both nuclear loss-of-function and cytoplasmic toxic gain-of-function phenotypes. While TDP-43 proteinopathy has been associated with defects in nucleocytoplasmic transport, this process is still poorly understood. Here we study the role of karyopherin-β1 (KPNB1) and other nuclear import receptors in regulating TDP-43 pathology. \r\n\r\nMethods: We used immunostaining, immunoprecipitation, biochemical and toxicity assays in cell lines, primary neuron and organotypic mouse brain slice cultures, to determine the impact of KPNB1 on the solubility, localization, and toxicity of pathological TDP-43 constructs. Postmortem patient brain and spinal cord tissue was stained to assess KPNB1 colocalization with TDP-43 inclusions. Turbidity assays were employed to study the dissolution and prevention of aggregation of recombinant TDP-43 fibrils in vitro. Fly models of TDP-43 proteinopathy were used to determine the effect of KPNB1 on their neurodegenerative phenotype in vivo. \r\n\r\nResults: We discovered that several members of the nuclear import receptor protein family can reduce the formation of pathological TDP-43 aggregates. Using KPNB1 as a model, we found that its activity depends on the prion-like C-terminal region of TDP-43, which mediates the co-aggregation with phenylalanine and glycine-rich nucleoporins (FG-Nups) such as Nup62. KPNB1 is recruited into these co-aggregates where it acts as a molecular chaperone that reverses aberrant phase transition of Nup62 and TDP-43. These findings are supported by the discovery that Nup62 and KPNB1 are also sequestered into pathological TDP-43 aggregates in ALS/FTD postmortem CNS tissue, and by the identification of the fly ortholog of KPNB1 as a strong protective modifier in Drosophila models of TDP-43 proteinopathy. Our results show that KPNB1 can rescue all hallmarks of TDP-43 pathology, by restoring its solubility and nuclear localization, and reducing neurodegeneration in cellular and animal models of ALS/FTD. \r\n\r\nConclusion: Our findings suggest a novel NLS-independent mechanism where, analogous to its canonical role in dissolving the diffusion barrier formed by FG-Nups in the nuclear pore, KPNB1 is recruited into TDP-43/FG-Nup co-aggregates present in TDP-43 proteinopathies and therapeutically reverses their deleterious phase transition and mislocalization, mitigating neurodegeneration. Graphical Abstract: [Figure not available: see fulltext.]."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/date> "2022-12-08" .
<https://discovery-pp.ucl.ac.uk/id/document/1527002> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/volume> "17" .
<https://discovery-pp.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery-pp.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> <http://xmlns.com/foaf/0.1/name> "BMC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/publisher> <https://discovery-pp.ucl.ac.uk/id/org/ext-df69af570ff4719131d9190cc31c0b76> .
<https://discovery-pp.ucl.ac.uk/id/publication/ext-17501326> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery-pp.ucl.ac.uk/id/publication/ext-17501326> <http://xmlns.com/foaf/0.1/name> "Molecular Neurodegeneration"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/isPartOf> <https://discovery-pp.ucl.ac.uk/id/publication/ext-17501326> .
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<https://discovery-pp.ucl.ac.uk/id/publication/ext-17501326> <http://purl.org/ontology/bibo/issn> "17501326" .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-d9a9a1e69904ba9a36322277a1b0386a> .
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<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery-pp.ucl.ac.uk/id/person/ext-d9a9a1e69904ba9a36322277a1b0386a> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-8e11d8c1b4fd7023b1ebae4d4042a7bd> .
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<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery-pp.ucl.ac.uk/id/person/ext-8e11d8c1b4fd7023b1ebae4d4042a7bd> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-f7851f90e1a1f8fabca8a152187724db> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery-pp.ucl.ac.uk/id/person/ext-f7851f90e1a1f8fabca8a152187724db> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-cf20df7c0249918858459f85e4d06b62> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery-pp.ucl.ac.uk/id/person/ext-cf20df7c0249918858459f85e4d06b62> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-b9cfc0c75d7e323327a2811df3a6aa9b> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery-pp.ucl.ac.uk/id/person/ext-b9cfc0c75d7e323327a2811df3a6aa9b> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-46f451a0f468118d9cf449d8dd9aa925> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery-pp.ucl.ac.uk/id/person/ext-46f451a0f468118d9cf449d8dd9aa925> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-5cd90100329439eae5772864fbb181e5> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery-pp.ucl.ac.uk/id/person/ext-5cd90100329439eae5772864fbb181e5> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-7b618e2fb7e5ce1bb1a0f7dcb1557ef3> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery-pp.ucl.ac.uk/id/person/ext-7b618e2fb7e5ce1bb1a0f7dcb1557ef3> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-ca442a5f6f0221cdce4693c2a07baa85> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery-pp.ucl.ac.uk/id/person/ext-ca442a5f6f0221cdce4693c2a07baa85> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-d46e78e6c2c7fb353e0540d3e95dbc0c> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery-pp.ucl.ac.uk/id/person/ext-d46e78e6c2c7fb353e0540d3e95dbc0c> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-239dcc154c1a2cae5706cab6e6b30e61> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery-pp.ucl.ac.uk/id/person/ext-239dcc154c1a2cae5706cab6e6b30e61> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-8fd0459b1d06eece25891463dcbc790c> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery-pp.ucl.ac.uk/id/person/ext-8fd0459b1d06eece25891463dcbc790c> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-2bb0e315093efa2c54c252ac141281f0> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery-pp.ucl.ac.uk/id/person/ext-2bb0e315093efa2c54c252ac141281f0> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-f99676fd21119164f48ecf9fe20d719d> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery-pp.ucl.ac.uk/id/person/ext-f99676fd21119164f48ecf9fe20d719d> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-9f717577dcf80e26a759218f9746a7be> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery-pp.ucl.ac.uk/id/person/ext-9f717577dcf80e26a759218f9746a7be> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-389a06e2839f093a8063f44df67661e6> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery-pp.ucl.ac.uk/id/person/ext-389a06e2839f093a8063f44df67661e6> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-30dfba7d3b333d607c606c84b1491238> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery-pp.ucl.ac.uk/id/person/ext-30dfba7d3b333d607c606c84b1491238> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-f208b019812c80ee8482af2d09efb904> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery-pp.ucl.ac.uk/id/person/ext-f208b019812c80ee8482af2d09efb904> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-a504d3ba07b586bf75c462853f44fbdc> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_19> <https://discovery-pp.ucl.ac.uk/id/person/ext-a504d3ba07b586bf75c462853f44fbdc> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-49dea67e15bee8d3a4ef95d3ad3284f3> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_20> <https://discovery-pp.ucl.ac.uk/id/person/ext-49dea67e15bee8d3a4ef95d3ad3284f3> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-4dd5ecfa5e6cf69ab0acfa92e38752d9> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_21> <https://discovery-pp.ucl.ac.uk/id/person/ext-4dd5ecfa5e6cf69ab0acfa92e38752d9> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-5d50f363f0d2a9a89d3fc54904a9d5b2> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_22> <https://discovery-pp.ucl.ac.uk/id/person/ext-5d50f363f0d2a9a89d3fc54904a9d5b2> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-fb2f8b9c98bbb0718af4990e863f67f1> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_23> <https://discovery-pp.ucl.ac.uk/id/person/ext-fb2f8b9c98bbb0718af4990e863f67f1> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-e1d4bce9af2381f81888f3476132353f> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_24> <https://discovery-pp.ucl.ac.uk/id/person/ext-e1d4bce9af2381f81888f3476132353f> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-36449417e8c44a3b8b6f13227d7a8abd> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_25> <https://discovery-pp.ucl.ac.uk/id/person/ext-36449417e8c44a3b8b6f13227d7a8abd> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-8e2a8851ee565dc3d7a8a11f2b8e05bc> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_26> <https://discovery-pp.ucl.ac.uk/id/person/ext-8e2a8851ee565dc3d7a8a11f2b8e05bc> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-2e3004a9a079dd9bf5b9a7ac8b0ceaa3> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_27> <https://discovery-pp.ucl.ac.uk/id/person/ext-2e3004a9a079dd9bf5b9a7ac8b0ceaa3> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/dc/terms/creator> <https://discovery-pp.ucl.ac.uk/id/person/ext-530a95556cee6516746d1c0f2c06dd61> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363> <http://purl.org/ontology/bibo/authorList> <https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> .
<https://discovery-pp.ucl.ac.uk/id/eprint/10167363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_28> <https://discovery-pp.ucl.ac.uk/id/person/ext-530a95556cee6516746d1c0f2c06dd61> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e11d8c1b4fd7023b1ebae4d4042a7bd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e11d8c1b4fd7023b1ebae4d4042a7bd> <http://xmlns.com/foaf/0.1/givenName> "Deepak"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e11d8c1b4fd7023b1ebae4d4042a7bd> <http://xmlns.com/foaf/0.1/familyName> "Chhangani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e11d8c1b4fd7023b1ebae4d4042a7bd> <http://xmlns.com/foaf/0.1/name> "Deepak Chhangani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-7b618e2fb7e5ce1bb1a0f7dcb1557ef3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-7b618e2fb7e5ce1bb1a0f7dcb1557ef3> <http://xmlns.com/foaf/0.1/givenName> "Chih-Wei"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-7b618e2fb7e5ce1bb1a0f7dcb1557ef3> <http://xmlns.com/foaf/0.1/familyName> "Tsai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-7b618e2fb7e5ce1bb1a0f7dcb1557ef3> <http://xmlns.com/foaf/0.1/name> "Chih-Wei Tsai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-49dea67e15bee8d3a4ef95d3ad3284f3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-49dea67e15bee8d3a4ef95d3ad3284f3> <http://xmlns.com/foaf/0.1/givenName> "Leonard"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-49dea67e15bee8d3a4ef95d3ad3284f3> <http://xmlns.com/foaf/0.1/familyName> "Petrucelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-49dea67e15bee8d3a4ef95d3ad3284f3> <http://xmlns.com/foaf/0.1/name> "Leonard Petrucelli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-ca442a5f6f0221cdce4693c2a07baa85> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-ca442a5f6f0221cdce4693c2a07baa85> <http://xmlns.com/foaf/0.1/givenName> "Gael"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-ca442a5f6f0221cdce4693c2a07baa85> <http://xmlns.com/foaf/0.1/familyName> "Fortin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-ca442a5f6f0221cdce4693c2a07baa85> <http://xmlns.com/foaf/0.1/name> "Gael Fortin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-46f451a0f468118d9cf449d8dd9aa925> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-46f451a0f468118d9cf449d8dd9aa925> <http://xmlns.com/foaf/0.1/givenName> "Xingli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-46f451a0f468118d9cf449d8dd9aa925> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-46f451a0f468118d9cf449d8dd9aa925> <http://xmlns.com/foaf/0.1/name> "Xingli Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e2a8851ee565dc3d7a8a11f2b8e05bc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e2a8851ee565dc3d7a8a11f2b8e05bc> <http://xmlns.com/foaf/0.1/givenName> "Sami J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e2a8851ee565dc3d7a8a11f2b8e05bc> <http://xmlns.com/foaf/0.1/familyName> "Barmada"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8e2a8851ee565dc3d7a8a11f2b8e05bc> <http://xmlns.com/foaf/0.1/name> "Sami J Barmada"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5cd90100329439eae5772864fbb181e5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5cd90100329439eae5772864fbb181e5> <http://xmlns.com/foaf/0.1/givenName> "Christian"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5cd90100329439eae5772864fbb181e5> <http://xmlns.com/foaf/0.1/familyName> "Puttinger"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5cd90100329439eae5772864fbb181e5> <http://xmlns.com/foaf/0.1/name> "Christian Puttinger"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-389a06e2839f093a8063f44df67661e6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-389a06e2839f093a8063f44df67661e6> <http://xmlns.com/foaf/0.1/givenName> "Cara L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-389a06e2839f093a8063f44df67661e6> <http://xmlns.com/foaf/0.1/familyName> "Croft"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-389a06e2839f093a8063f44df67661e6> <http://xmlns.com/foaf/0.1/name> "Cara L Croft"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8fd0459b1d06eece25891463dcbc790c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8fd0459b1d06eece25891463dcbc790c> <http://xmlns.com/foaf/0.1/givenName> "Feilin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8fd0459b1d06eece25891463dcbc790c> <http://xmlns.com/foaf/0.1/familyName> "Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-8fd0459b1d06eece25891463dcbc790c> <http://xmlns.com/foaf/0.1/name> "Feilin Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b9cfc0c75d7e323327a2811df3a6aa9b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b9cfc0c75d7e323327a2811df3a6aa9b> <http://xmlns.com/foaf/0.1/givenName> "Jannifer H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b9cfc0c75d7e323327a2811df3a6aa9b> <http://xmlns.com/foaf/0.1/familyName> "Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-b9cfc0c75d7e323327a2811df3a6aa9b> <http://xmlns.com/foaf/0.1/name> "Jannifer H Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d46e78e6c2c7fb353e0540d3e95dbc0c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d46e78e6c2c7fb353e0540d3e95dbc0c> <http://xmlns.com/foaf/0.1/givenName> "Dmytro"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d46e78e6c2c7fb353e0540d3e95dbc0c> <http://xmlns.com/foaf/0.1/familyName> "Morderer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d46e78e6c2c7fb353e0540d3e95dbc0c> <http://xmlns.com/foaf/0.1/name> "Dmytro Morderer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d9a9a1e69904ba9a36322277a1b0386a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d9a9a1e69904ba9a36322277a1b0386a> <http://xmlns.com/foaf/0.1/givenName> "Bilal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d9a9a1e69904ba9a36322277a1b0386a> <http://xmlns.com/foaf/0.1/familyName> "Khalil"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-d9a9a1e69904ba9a36322277a1b0386a> <http://xmlns.com/foaf/0.1/name> "Bilal Khalil"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-9f717577dcf80e26a759218f9746a7be> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-9f717577dcf80e26a759218f9746a7be> <http://xmlns.com/foaf/0.1/givenName> "Ching-Chieh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-9f717577dcf80e26a759218f9746a7be> <http://xmlns.com/foaf/0.1/familyName> "Chou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-9f717577dcf80e26a759218f9746a7be> <http://xmlns.com/foaf/0.1/name> "Ching-Chieh Chou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-fb2f8b9c98bbb0718af4990e863f67f1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-fb2f8b9c98bbb0718af4990e863f67f1> <http://xmlns.com/foaf/0.1/givenName> "Ke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-fb2f8b9c98bbb0718af4990e863f67f1> <http://xmlns.com/foaf/0.1/familyName> "Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-fb2f8b9c98bbb0718af4990e863f67f1> <http://xmlns.com/foaf/0.1/name> "Ke Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-f99676fd21119164f48ecf9fe20d719d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-f99676fd21119164f48ecf9fe20d719d> <http://xmlns.com/foaf/0.1/givenName> "Jingjiao"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-f99676fd21119164f48ecf9fe20d719d> <http://xmlns.com/foaf/0.1/familyName> "Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-f99676fd21119164f48ecf9fe20d719d> <http://xmlns.com/foaf/0.1/name> "Jingjiao Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-30dfba7d3b333d607c606c84b1491238> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-30dfba7d3b333d607c606c84b1491238> <http://xmlns.com/foaf/0.1/givenName> "Amanda M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-30dfba7d3b333d607c606c84b1491238> <http://xmlns.com/foaf/0.1/familyName> "Gleixner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-30dfba7d3b333d607c606c84b1491238> <http://xmlns.com/foaf/0.1/name> "Amanda M Gleixner"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-530a95556cee6516746d1c0f2c06dd61> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-530a95556cee6516746d1c0f2c06dd61> <http://xmlns.com/foaf/0.1/givenName> "Wilfried"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-530a95556cee6516746d1c0f2c06dd61> <http://xmlns.com/foaf/0.1/familyName> "Rossoll"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-530a95556cee6516746d1c0f2c06dd61> <http://xmlns.com/foaf/0.1/name> "Wilfried Rossoll"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-cf20df7c0249918858459f85e4d06b62> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-cf20df7c0249918858459f85e4d06b62> <http://xmlns.com/foaf/0.1/givenName> "Courtney L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-cf20df7c0249918858459f85e4d06b62> <http://xmlns.com/foaf/0.1/familyName> "Smith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-cf20df7c0249918858459f85e4d06b62> <http://xmlns.com/foaf/0.1/name> "Courtney L Smith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-e1d4bce9af2381f81888f3476132353f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-e1d4bce9af2381f81888f3476132353f> <http://xmlns.com/foaf/0.1/givenName> "James"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-e1d4bce9af2381f81888f3476132353f> <http://xmlns.com/foaf/0.1/familyName> "Shorter"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-e1d4bce9af2381f81888f3476132353f> <http://xmlns.com/foaf/0.1/name> "James Shorter"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a504d3ba07b586bf75c462853f44fbdc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a504d3ba07b586bf75c462853f44fbdc> <http://xmlns.com/foaf/0.1/givenName> "Todd E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a504d3ba07b586bf75c462853f44fbdc> <http://xmlns.com/foaf/0.1/familyName> "Golde"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-a504d3ba07b586bf75c462853f44fbdc> <http://xmlns.com/foaf/0.1/name> "Todd E Golde"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-4dd5ecfa5e6cf69ab0acfa92e38752d9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-4dd5ecfa5e6cf69ab0acfa92e38752d9> <http://xmlns.com/foaf/0.1/givenName> "Bjorn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-4dd5ecfa5e6cf69ab0acfa92e38752d9> <http://xmlns.com/foaf/0.1/familyName> "Oskarsson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-4dd5ecfa5e6cf69ab0acfa92e38752d9> <http://xmlns.com/foaf/0.1/name> "Bjorn Oskarsson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-36449417e8c44a3b8b6f13227d7a8abd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-36449417e8c44a3b8b6f13227d7a8abd> <http://xmlns.com/foaf/0.1/givenName> "Shige H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-36449417e8c44a3b8b6f13227d7a8abd> <http://xmlns.com/foaf/0.1/familyName> "Yoshimura"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-36449417e8c44a3b8b6f13227d7a8abd> <http://xmlns.com/foaf/0.1/name> "Shige H Yoshimura"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/person/ext-5d50f363f0d2a9a89d3fc54904a9d5b2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
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<https://discovery-pp.ucl.ac.uk/id/person/ext-2e3004a9a079dd9bf5b9a7ac8b0ceaa3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
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