eprintid: 10188038 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/18/80/38 datestamp: 2024-02-28 12:32:14 lastmod: 2024-02-28 12:32:14 status_changed: 2024-02-28 12:32:14 type: article metadata_visibility: show sword_depositor: 699 creators_name: Sharma, Aditi creators_name: Papanikolaou, Nikoleta creators_name: Abou Sherif, Sara creators_name: Dimakopolou, Anastasia creators_name: Thaventhiran, Thilipan creators_name: Go, Cara creators_name: Entwistle, Olivia Holtermann creators_name: Brown, Adrian creators_name: Luo, Rong creators_name: Jha, Rama creators_name: Prakash, Anavi creators_name: Khalifa, Dalia creators_name: Lewis, Hannah creators_name: Ramaraju, Sruthi creators_name: Leeds, Anthony R creators_name: Chahal, Harvinder creators_name: Purkayastha, Sanjay creators_name: Henkel, Ralf creators_name: Minhas, Sukhbinder creators_name: Frost, Gary creators_name: Dhillo, Waljit S creators_name: Jayasena, Channa N title: Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G94 keywords: male reproduction, male fertility, obesity, spermatogenesis, weight loss, sperm quality note: © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com abstract: INTRODUCTION: Obesity increases risks of male infertility, but bariatric surgery does not improve semen quality. Recent uncontrolled studies suggest that a low-energy diet (LED) improves semen quality. Further evaluation within a randomized, controlled setting is warranted. METHODS: Men with obesity (18-60 years) with normal sperm concentration (normal count) (n = 24) or oligozoospermia (n = 43) were randomized 1:1 to either 800 kcal/day LED for 16 weeks or control, brief dietary intervention (BDI) with 16 weeks' observation. Semen parameters were compared at baseline and 16 weeks. RESULTS: Mean age of men with normal count was 39.4 ± 6.4 in BDI and 40.2 ± 9.6 years in the LED group. Mean age of men with oligozoospermia was 39.5 ± 7.5 in BDI and 37.7 ± 6.6 years in the LED group. LED caused more weight loss than BDI in men with normal count (14.4 vs 6.3 kg; P < .001) and men with oligozoospermia (17.6 vs 1.8 kg; P < .001). Compared with baseline, in men with normal count total motility (TM) increased 48 ± 17% to 60 ± 10% (P < .05) after LED, and 52 ± 8% to 61 ± 6% (P < .0001) after BDI; progressive motility (PM) increased 41 ± 16% to 53 ± 10% (P < .05) after LED, and 45 ± 8% to 54 ± 65% (P < .001) after BDI. In men with oligozoospermia compared with baseline, TM increased 35% [26] to 52% [16] (P < .05) after LED, and 43% [28] to 50% [23] (P = .0587) after BDI; PM increased 29% [23] to 46% [18] (P < .05) after LED, and 33% [25] to 44% [25] (P < .05) after BDI. No differences in postintervention TM or PM were observed between LED and BDI groups in men with normal count or oligozoospermia. CONCLUSION: LED or BDI may be sufficient to improve sperm motility in men with obesity. The effects of paternal dietary intervention on fertility outcomes requires investigation. date: 2024-02 date_type: published publisher: ENDOCRINE SOC official_url: http://dx.doi.org/10.1210/clinem/dgad523 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2082288 doi: 10.1210/clinem/dgad523 medium: Print pii: 7258743 lyricists_name: Brown, Adrian lyricists_id: ATURN01 actors_name: Brown, Adrian actors_id: ATURN01 actors_role: owner funding_acknowledgements: [The studies were supported by Imperial NIHR Clinical Research Facility and the NIHR Clinical Research Network (CRN). We would like to particularly thank the staff at the Andrology department of Hammersmith hospital for their contribution to this study and]; [Imperial NIHR Clinical Research Facility]; [NIHR Clinical Research Network (CRN)] full_text_status: public publication: The Journal of Clinical Endocrinology & Metabolism volume: 109 number: 2 pagerange: 449-460 pages: 12 event_location: United States issn: 0021-972X citation: Sharma, Aditi; Papanikolaou, Nikoleta; Abou Sherif, Sara; Dimakopolou, Anastasia; Thaventhiran, Thilipan; Go, Cara; Entwistle, Olivia Holtermann; ... Jayasena, Channa N; + view all <#> Sharma, Aditi; Papanikolaou, Nikoleta; Abou Sherif, Sara; Dimakopolou, Anastasia; Thaventhiran, Thilipan; Go, Cara; Entwistle, Olivia Holtermann; Brown, Adrian; Luo, Rong; Jha, Rama; Prakash, Anavi; Khalifa, Dalia; Lewis, Hannah; Ramaraju, Sruthi; Leeds, Anthony R; Chahal, Harvinder; Purkayastha, Sanjay; Henkel, Ralf; Minhas, Sukhbinder; Frost, Gary; Dhillo, Waljit S; Jayasena, Channa N; - view fewer <#> (2024) Improvements in Sperm Motility Following Low- or High-Intensity Dietary Interventions in Men With Obesity. The Journal of Clinical Endocrinology & Metabolism , 109 (2) pp. 449-460. 10.1210/clinem/dgad523 <https://doi.org/10.1210/clinem%2Fdgad523>. Green open access document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10188038/1/Sharma%202024%20Andrology%20Study.pdf