TY  - JOUR
SN  - 1065-9471
IS  - 3
TI  - What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?
VL  - 45
AV  - public
KW  - Auditory
KW  -  hippocampal
KW  -  memory
KW  -  neuroscience
KW  -  Animals
KW  -  Humans
KW  -  Tinnitus
KW  -  Hippocampus
KW  -  Parahippocampal Gyrus
KW  -  Limbic System
KW  -  Auditory Cortex
ID  - discovery10188200
N1  - © 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UR  - https://doi.org/10.1002/hbm.26627
JF  - Human Brain Mapping
N2  - The hippocampus and parahippocampal gyrus have been implicated as part of a tinnitus network by a number of studies. These structures are usually considered in the context of a ?limbic system,? a concept typically invoked to explain the emotional response to tinnitus. Despite this common framing, it is not apparent from current literature that this is necessarily the main functional role of these structures in persistent tinnitus. Here, we highlight a different role that encompasses their most commonly implicated functional position within the brain?that is, as a memory system. We consider tinnitus as an auditory object that is held in memory, which may be made persistent by associated activity from the hippocampus and parahippocampal gyrus. Evidence from animal and human studies implicating these structures in tinnitus is reviewed and used as an anchor for this hypothesis. We highlight the potential for the hippocampus/parahippocampal gyrus to facilitate maintenance of the memory of the tinnitus percept via communication with auditory cortex, rather than (or in addition to) mediating emotional responses to this percept.
PB  - Wiley
Y1  - 2024/02/15/
A1  - Berger, JI
A1  - Billig, AJ
A1  - Sedley, W
A1  - Kumar, S
A1  - Griffiths, TD
A1  - Gander, PE
ER  -