%L discovery10190431
%C England
%I Elsevier BV
%A MA van Dam
%A OD Bijlstra
%A RA Faber
%A MI Warmerdam
%A MP Achiam
%A L Boni
%A RA Cahill
%A M Chand
%A M Diana
%A S Gioux
%A S Kruijff
%A JR Van der Vorst
%A RJ Rosenthal
%A K Polom
%A AL Vahrmeijer
%A JSD Mieog
%V 50
%D 2024
%T Consensus conference statement on fluorescence-guided surgery (FGS) ESSO course on fluorescence-guided surgery
%O This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third-party material in this article are included in the Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
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%X Background: Fluorescence-guided surgery (FGS) has emerged as an innovative technique with promising applications in various surgical specialties. However, clinical implementation is hampered by limited availability of evidence-based reference work supporting the translation towards standard-of-care use in surgical practice. Therefore, we developed a consensus statement on current applications of FGS. Methods: During an international FGS course, participants anonymously voted on 36 statements. Consensus was defined as agreement ≥70% with participation grade of ≥80%. All participants of the questionnaire were stratified for user and handling experience within five domains of applicability (lymphatics & lymph node imaging; tissue perfusion; biliary anatomy and urinary tracts; tumor imaging in colorectal, HPB, and endocrine surgery, and quantification and (tumor-) targeted imaging). Results were pooled to determine consensus for each statement within the respective sections based on the degree of agreement. Results: In total 43/52 (81%) course participants were eligible as voting members for consensus, comprising the expert panel (n = 12) and trained users (n = 31). Consensus was achieved in 17 out of 36 (45%) statements with highest level of agreement for application of FGS in tissue perfusion and biliary/urinary tract visualization (71% and 67%, respectively) and lowest within the tumor imaging section (0%). Conclusions: FGS is currently established for tissue perfusion and vital structure imaging. Lymphatics & lymph node imaging in breast cancer and melanoma are evolving, and tumor tissue imaging holds promise in early-phase trials. Quantification and (tumor-)targeted imaging are advancing toward clinical validation. Additional research is needed for tumor imaging due to a lack of consensus.
%J European Journal of Surgical Oncology
%K Conference consensus statement, Fluorescence, Fluorescence-guided surgery, Imaging, Indocyanine green, Humans, Female, Fluorescence, Surgery, Computer-Assisted, Breast Neoplasms, Lymph Nodes, Specialties, Surgical
%N 2