eprintid: 10190594
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/19/05/94
datestamp: 2024-04-12 12:37:00
lastmod: 2024-04-12 12:37:00
status_changed: 2024-04-12 12:37:00
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Rodríguez-Pombo, L
creators_name: Carou-Senra, P
creators_name: Rodríguez-Martínez, E
creators_name: Januskaite, P
creators_name: Rial, C
creators_name: Félix, P
creators_name: Alvarez-Lorenzo, C
creators_name: Basit, AW
creators_name: Goyanes, A
title: Customizable orodispersible films: Inkjet printing and data matrix encoding for personalized hydrocortisone dosing
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: 2D printed drug products, Data-enriched edible pharmaceuticals, Desktop inkjet printing, Hydrocortisone, Personalized medicine
note: © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
abstract: The aim of this study was to exploit the versatility of inkjet printing to develop flexible doses of drug-loaded orodispersible films that encoded information in a data matrix pattern, and to introduce a specialised data matrix-generator software specifically focused on the healthcare sector. Pharma-inks (drug-loaded inks) containing hydrocortisone (HC) were developed and characterised based on their rheological properties and drug content. Different strategies were investigated to improve HC solubility: formation of β-cyclodextrin complexes, Soluplus® based micelles, and the use of co-solvent systems. The software automatically adapted the data matrix size and identified the number of layers for printing. HC content deposited in each film layer was measured, and it was found that the proportion of co-solvent used directly affected the drug solubility and simultaneously played a role in the modification of the viscosity and surface tension of the inks. The formation of β-cyclodextrin complexes improved the drug quantity deposited in each layer. On the contrary, micelle-based inks were not suitable for printing. Orodispersible films containing flexible and low doses of personalised HC were successfully prepared, and the development of a code generator software oriented to medical use provided an additional, innovative, and revolutionary advantage to personalised medicine safety and accessibility.
date: 2024-04-25
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.ijpharm.2024.124005
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2261603
doi: 10.1016/j.ijpharm.2024.124005
medium: Print-Electronic
pii: S0378-5173(24)00239-4
lyricists_name: Basit, Abdul
lyricists_name: Januskaite, Patricija
lyricists_id: ABASI56
lyricists_id: JANUS91
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: International Journal of Pharmaceutics
volume: 655
article_number: 124005
event_location: Netherlands
issn: 0378-5173
citation:        Rodríguez-Pombo, L;    Carou-Senra, P;    Rodríguez-Martínez, E;    Januskaite, P;    Rial, C;    Félix, P;    Alvarez-Lorenzo, C;         ... Goyanes, A; + view all <#>        Rodríguez-Pombo, L;  Carou-Senra, P;  Rodríguez-Martínez, E;  Januskaite, P;  Rial, C;  Félix, P;  Alvarez-Lorenzo, C;  Basit, AW;  Goyanes, A;   - view fewer <#>    (2024)    Customizable orodispersible films: Inkjet printing and data matrix encoding for personalized hydrocortisone dosing.                   International Journal of Pharmaceutics , 655     , Article 124005.  10.1016/j.ijpharm.2024.124005 <https://doi.org/10.1016/j.ijpharm.2024.124005>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10190594/1/1-s2.0-S0378517324002394-main.pdf