%0 Conference Paper
%A Dymerska, Barbara
%A Cardoso, Pedro
%A Mahr, Nina
%A Matt, Eva
%A Fischmeister, Florian
%A Beisteiner, Roland
%A Trattnig, Siegfried
%A Robinson, Simon Daniel
%B ISMRM 24tj  Annual Meeting
%C Singapore, Singapore
%D 2016
%F discovery:10190795
%T Investigating the Impact of Temporal Signal Fluctuations and Local Effective Echo Times on Indices of BOLD Sensitivity in Healthy Subjects and Tumor Patients at 7T
%U https://discovery-pp.ucl.ac.uk/id/eprint/10190795/
%X Temporal signal fluctuations (tSNR) and local effective echo time (TEₗₒ꜀ₐₗ) are explored and their influence on BOLD sensitivity is investigated at 7T for healthy subjects and tumor patients, where prominent spatial variations in those two measures are expected. We show that tSNR may indicate sufficient sensitivity to detect activation but that BOLD sensitivity may be dramatically reduced by changes in TEₗₒ꜀ₐₗ close to pathologies and vital brain functions (motor, speech, auditory). Neglecting local TE variations can thus lead to false negative results in clinical fMRI. We thus suggest a new BOLD sensitivity metric based on TEₗₒ꜀ₐₗ∙tSNR.
%Z This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.