eprintid: 10191616 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/19/16/16 datestamp: 2024-05-03 14:46:08 lastmod: 2024-05-03 14:46:08 status_changed: 2024-05-03 14:46:08 type: article metadata_visibility: show sword_depositor: 699 creators_name: Adhami, Masoud creators_name: Picco, Camila J creators_name: Detamornrat, Usanee creators_name: Anjani, Qonita K creators_name: Cornelius, Victoria A creators_name: Robles-Martinez, Pamela creators_name: Margariti, Andriana creators_name: Donnelly, Ryan F creators_name: Domínguez-Robles, Juan creators_name: Larrañeta, Eneko title: Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 keywords: 3D printing, Digital light processing, Vascular grafts, Clopidogrel note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. abstract: The leading cause of death worldwide and a significant factor in decreased quality of life are the cardiovascular diseases. Endovascular operations like angioplasty, stent placement, or atherectomy are often used in vascular surgery to either dilate a narrowed blood artery or remove a blockage. As an alternative, a vascular transplant may be utilised to replace or bypass a dysfunctional or blocked blood vessel. Despite the advancements in endovascular surgery and its popularisation over the past few decades, vascular bypass grafting remains prevalent and is considered the best option for patients in need of long-term revascularisation treatments. Consequently, the demand for synthetic vascular grafts composed of biocompatible materials persists. To address this need, biodegradable clopidogrel (CLOP)-loaded vascular grafts have been fabricated using the digital light processing (DLP) 3D printing technique. A mixture of polylactic acid-polyurethane acrylate (PLA-PUA), low molecular weight polycaprolactone (L-PCL), and CLOP was used to achieve the required mechanical and biological properties for vascular grafts. The 3D printing technology provides precise detail in terms of shape and size, which lead to the fabrication of customised vascular grafts. The fabricated vascular grafts were fully characterised using different techniques, and finally, the drug release was evaluated. Results suggested that the performed 3D-printed small-diameter vascular grafts containing the highest CLOP cargo (20% w/w) were able to provide a sustained drug release for up to 27 days. Furthermore, all the CLOP-loaded 3D-printed materials resulted in a substantial reduction of the platelet deposition across their surface compared to the blank materials containing no drug. Haemolysis percentage for all the 3D-printed samples was lower than 5%. Moreover, 3D-printed materials were able to provide a supportive environment for cellular attachment, viability, and growth. A substantial increase in cell growth was detected between the blank and drug-loaded grafts. date: 2024-06 date_type: published publisher: Springer Science and Business Media LLC official_url: https://doi.org/10.1007/s13346-023-01484-8 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2272295 doi: 10.1007/s13346-023-01484-8 lyricists_name: Robles Martinez, Pamela lyricists_id: PROBL47 actors_name: Robles Martinez, Pamela actors_name: Harris, Jean actors_id: PROBL47 actors_id: JAHAR68 actors_role: owner actors_role: impersonator full_text_status: public publication: Drug Delivery and Translational Research volume: 14 pagerange: 1693-1707 issn: 2190-393X citation: Adhami, Masoud; Picco, Camila J; Detamornrat, Usanee; Anjani, Qonita K; Cornelius, Victoria A; Robles-Martinez, Pamela; Margariti, Andriana; ... Larrañeta, Eneko; + view all <#> Adhami, Masoud; Picco, Camila J; Detamornrat, Usanee; Anjani, Qonita K; Cornelius, Victoria A; Robles-Martinez, Pamela; Margariti, Andriana; Donnelly, Ryan F; Domínguez-Robles, Juan; Larrañeta, Eneko; - view fewer <#> (2024) Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing. Drug Delivery and Translational Research , 14 pp. 1693-1707. 10.1007/s13346-023-01484-8 <https://doi.org/10.1007/s13346-023-01484-8>. Green open access document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10191616/1/s13346-023-01484-8.pdf