eprintid: 10191973
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/19/19/73
datestamp: 2024-05-09 07:06:26
lastmod: 2024-05-09 07:06:26
status_changed: 2024-05-09 07:06:26
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Kurvits, Lille
creators_name: Stenner, Max-Philipp
creators_name: Guo, Siqi
creators_name: Neumann, Wolf-Julian
creators_name: Haggard, Patrick
creators_name: Ganos, Christos
title: Rapid Compensation for Noisy Voluntary Movements in Adults with Primary Tic Disorders
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D05
divisions: F69
keywords: Primary tic disorders; Tourette syndrome;
sensorimotor integration; sensorimotor noise; movement
variability
note: Copyright © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, https://creativecommons.org/licenses/by-nc-nd/4.0/, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
abstract: Background:
It has been proposed that tics and premonitory urges in primary tic disorders (PTD), like Tourette syndrome, are a manifestation of sensorimotor noise. However, patients with tics show no obvious movement imprecision in everyday life. One reason could be that patients have strategies to compensate for noise that disrupts performance (ie, noise that is task-relevant).
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Objectives:
Our goal was to unmask effects of elevated sensorimotor noise on the variability of voluntary movements in patients with PTD.
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Methods:
We tested 30 adult patients with PTD (23 male) and 30 matched controls in a reaching task designed to unmask latent noise. Subjects reached to targets whose shape allowed for variability either in movement direction or extent. This enabled us to decompose variability into task-relevant versus less task-relevant components, where the latter should be less affected by compensatory strategies than the former. In alternating blocks, the task-relevant target dimension switched, allowing us to explore the temporal dynamics with which participants adjusted movement variability to changes in task demands.
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Results:
Both groups accurately reached to targets, and adjusted movement precision based on target shape. However, when task-relevant dimensions of the target changed, patients initially produced movements that were more variable than controls, before regaining precision after several reaches. This effect persisted across repeated changes in the task-relevant dimension across the experiment, and therefore did not reflect an effect of novelty, or differences in learning.
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Conclusions:
Our results suggest that patients with PTD generate noisier voluntary movements compared with controls, but rapidly compensate according to current task demands. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
date: 2024-04-25
date_type: published
publisher: Wiley
official_url: http://dx.doi.org/10.1002/mds.29775
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2272878
doi: 10.1002/mds.29775
medium: Print-Electronic
lyricists_name: Haggard, Patrick
lyricists_id: PHAGG98
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
funding_acknowledgements: 92977 [VolkswagenStiftung Freigeist Fellowship]; FKZ01GQ1802 [Bundesministerium für Bildung und Forschung]; 424778381 - TRR 295 [Deutsche Forschungsgemeinschaft]; 101077060 [European Union]
full_text_status: public
publication: Movement Disorders
event_location: United States
issn: 0885-3185
citation:        Kurvits, Lille;    Stenner, Max-Philipp;    Guo, Siqi;    Neumann, Wolf-Julian;    Haggard, Patrick;    Ganos, Christos;      (2024)    Rapid Compensation for Noisy Voluntary Movements in Adults with Primary Tic Disorders.                   Movement Disorders        10.1002/mds.29775 <https://doi.org/10.1002/mds.29775>.    (In press).    Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10191973/1/Movement%20Disorders%20-%202024%20-%20Kurvits%20-%20Rapid%20Compensation%20for%20Noisy%20Voluntary%20Movements%20in%20Adults%20with%20Primary%20Tic%20Disorders.pdf