@article{discovery10192167,
            note = {{\copyright} 2024 - The authors. Published by IOS Press. This is an Open Access article distributed under the terms
of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0).},
            year = {2024},
           title = {Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials initiative},
         journal = {Journal of Parkinson's Disease},
           month = {April},
       publisher = {IOS Press},
        abstract = {In 2011, the UK medical research charity Cure Parkinson's set up the international Linked Clinical Trials (iLCT) committee to help expedite the clinical testing of potentially disease modifying therapies for Parkinson's disease (PD). The first committee meeting was held at the Van Andel Institute in Grand Rapids, Michigan in 2012. This group of PD experts has subsequently met annually to assess and prioritize agents that may slow the progression of this neurodegenerative condition, using a systematic approach based on preclinical, epidemiological and, where possible, clinical data. Over the last 12 years, 171 unique agents have been evaluated by the iLCT committee, and there have been 21 completed clinical studies and 20 ongoing trials associated with the initiative. In this review, we briefly outline the iLCT process as well as the clinical development and outcomes of some of the top prioritized agents. We also discuss a few of the lessons that have been learnt, and we conclude with a perspective on what the next decade may bring, including the introduction of multi-arm, multi-stage clinical trial platforms and the possibility of combination therapies for PD.},
            issn = {1877-7171},
          author = {Wyse, Richard K and Isaacs, Tom and Barker, Roger A and Cookson, Mark R and Dawson, Ted M and Devos, David and Dexter, David T and Duffen, Joy and Federoff, Howard and Fiske, Brian and Foltynie, Thomas and Fox, Susan and Greenamyre, J Timothy and Kieburtz, Karl and Kordower, Jeffrey H and Krainc, Dimitri and Matthews, Helen and Moore, Darren J and Mursaleen, Leah and Schwarzschild, Michael A and Stott, Simon RW and Sulzer, David and Svenningsson, Per and Tanner, Caroline M and Carroll, Camille and Simon, David K and Brundin, Patrik},
             url = {http://doi.org/10.3233/JPD-230363},
        keywords = {Clinical trials, Parkinson's disease, disease modification, drug repurposing, neuroprotection}
}