eprintid: 10192734 rev_number: 6 eprint_status: archive userid: 699 dir: disk0/10/19/27/34 datestamp: 2024-05-24 09:16:48 lastmod: 2024-05-24 09:16:48 status_changed: 2024-05-24 09:16:48 type: article metadata_visibility: show sword_depositor: 699 creators_name: Sweeney, Paul W creators_name: Walsh, Claire creators_name: Walker‐Samuel, Simon creators_name: Shipley, Rebecca J title: A three-dimensional, discrete-continuum model of blood pressure in microvascular networks ispublished: inpress divisions: UCL divisions: B04 divisions: C05 divisions: F45 note: © 2024 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: We present a 3D discrete‐continuum model to simulate blood pressure in large microvascular tissues in the absence of known capillary network architecture. Our hybrid approach combines a 1D Poiseuille flow description for large, discrete arteriolar and venular networks coupled to a continuum‐based Darcy model, point sources of flux, for transport in the capillary bed. We evaluate our hybrid approach using a vascular network imaged from the mouse brain medulla/pons using multi‐fluorescence high‐resolution episcopic microscopy (MF‐HREM). We use the fully‐resolved vascular network to predict the hydraulic conductivity of the capillary network and generate a fully‐discrete pressure solution to benchmark against. Our results demonstrate that the discrete‐continuum methodology is a computationally feasible and effective tool for predicting blood pressure in real‐world microvascular tissues when capillary microvessels are poorly defined. date: 2024-05-21 date_type: published publisher: Wiley official_url: http://dx.doi.org/10.1002/cnm.3832 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2277936 doi: 10.1002/cnm.3832 lyricists_name: Shipley, Rebecca lyricists_id: RSHIP58 actors_name: Shipley, Rebecca actors_id: RSHIP58 actors_role: owner full_text_status: public publication: International Journal for Numerical Methods in Biomedical Engineering article_number: e3832 issn: 2040-7939 citation: Sweeney, Paul W; Walsh, Claire; Walker‐Samuel, Simon; Shipley, Rebecca J; (2024) A three-dimensional, discrete-continuum model of blood pressure in microvascular networks. International Journal for Numerical Methods in Biomedical Engineering , Article e3832. 10.1002/cnm.3832 <https://doi.org/10.1002/cnm.3832>. (In press). Green open access document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10192734/1/Numer%20Methods%20Biomed%20Eng%20-%202024%20-%20Sweeney%20-%20A%20three%25E2%2580%2590dimensional%20%20discrete%25E2%2580%2590continuum%20model%20of%20blood%20pressure%20in.pdf