eprintid: 10194257 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/19/42/57 datestamp: 2024-07-08 14:51:05 lastmod: 2024-07-08 14:51:05 status_changed: 2024-07-08 14:51:05 type: article metadata_visibility: show sword_depositor: 699 creators_name: Ballerini, Alice creators_name: Biagioli, Niccolò creators_name: Carbone, Chiara creators_name: Chiari, Annalisa creators_name: Tondelli, Manuela creators_name: Vinceti, Giulia creators_name: Bedin, Roberta creators_name: Malagoli, Marcella creators_name: Genovese, Maurilio creators_name: Scolastico, Simona creators_name: Giovannini, Giada creators_name: Pugnaghi, Matteo creators_name: Orlandi, Niccolò creators_name: Lemieux, Louis creators_name: Meletti, Stefano creators_name: Zamboni, Giovanna creators_name: Vaudano, Anna Elisabetta title: Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer's disease biomarkers ispublished: inpress divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F81 keywords: CSF biomarkers, late-onset temporal lobe epilepsy, mild cognitive impairment, phosphorylated tau, structural MRI, β-amyloid note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Considering the growing age of the world population, the incidence of epilepsy in older adults is expected to increase significantly. It has been suggested that late-onset temporal lobe epilepsy (LO-TLE) may be neurodegenerative in origin and overlap with Alzheimer's Disease (AD). Herein, we aimed to characterize the pattern of cortical atrophy and cerebrospinal fluid (CSF) biomarkers of AD (total and phosphorylated tau, and β-amyloid) in a selected population of LO-TLE of unknown origin. We prospectively enrolled individuals with temporal lobe epilepsy onset after the age of 50 and no cognitive impairment. They underwent a structural MRI scan and CSF biomarkers measurement. Imaging and biomarkers data were compared to three retrospectively collected groups: (i) age-sex-matched healthy controls, (ii) patients with Mild Cognitive Impairment (MCI) and abnormal CSF AD biomarkers (MCI-AD), and (iii) patients with MCI and normal CSF AD biomarkers (MCI-noAD). From a pool of 52 patients, twenty consecutive eligible LO-TLE patients with a mean disease duration of 1.8 years were recruited. As control populations, 25 patients with MCI-AD, 25 patients with MCI-noAD, and 25 healthy controls were enrolled. CSF biomarkers returned normal values in LO-TLE, significantly different from patients with MCI due to AD. There were no differences in cortico-subcortical atrophy between epilepsy patients and healthy controls, while patients with MCI demonstrated widespread injuries of cortico-subcortical structures. Individuals with a late-onset form of temporal lobe epilepsy, characterized by short disease duration and normal CSF β-amyloid and tau protein levels, showed patterns of cortical thickness and subcortical volumes not significantly different from healthy controls, but highly different from patients with MCI, either due to Alzheimer's Disease or not. date: 2024-06-25 date_type: published publisher: Oxford University Press (OUP) official_url: https://doi.org/10.1093/brain/awae207 full_text_type: other language: eng verified: verified_manual elements_id: 2292006 doi: 10.1093/brain/awae207 medium: Print-Electronic pii: 7698175 lyricists_name: Lemieux, Louis lyricists_id: LLEMI59 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: restricted publication: Brain event_location: England issn: 0006-8950 citation: Ballerini, Alice; Biagioli, Niccolò; Carbone, Chiara; Chiari, Annalisa; Tondelli, Manuela; Vinceti, Giulia; Bedin, Roberta; ... Vaudano, Anna Elisabetta; + view all <#> Ballerini, Alice; Biagioli, Niccolò; Carbone, Chiara; Chiari, Annalisa; Tondelli, Manuela; Vinceti, Giulia; Bedin, Roberta; Malagoli, Marcella; Genovese, Maurilio; Scolastico, Simona; Giovannini, Giada; Pugnaghi, Matteo; Orlandi, Niccolò; Lemieux, Louis; Meletti, Stefano; Zamboni, Giovanna; Vaudano, Anna Elisabetta; - view fewer <#> (2024) Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer's disease biomarkers. Brain 10.1093/brain/awae207 <https://doi.org/10.1093/brain%2Fawae207>. (In press). document_url: https://discovery-pp.ucl.ac.uk/id/eprint/10194257/1/awae207.pdf