@article{discovery1337498,
         journal = {PLoS Negl Trop Dis},
            year = {2011},
          volume = {5},
           title = {Integrated dataset of screening hits against multiple neglected disease pathogens.},
            note = {{\copyright} 2011 Nwaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: Work produced was entirely supported by WHO public funds; no grants or external funding was used to maintain activities. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.},
           month = {December},
          number = {12},
        keywords = {Antiparasitic Agents, Drug Discovery, Drug Evaluation, Preclinical, Humans, Neglected Diseases, Parasitic Diseases},
          author = {Nwaka, S and Besson, D and Ramirez, B and Maes, L and Matheeussen, A and Bickle, Q and Mansour, NR and Yousif, F and Townson, S and Gokool, S and Cho-Ngwa, F and Samje, M and Misra-Bhattacharya, S and Murthy, PK and Fakorede, F and Paris, JM and Yeates, C and Ridley, R and Van Voorhis, WC and Geary, T},
            issn = {1935-2735},
             url = {http://dx.doi.org/10.1371/journal.pntd.0001412},
        abstract = {New chemical entities are desperately needed that overcome the limitations of existing drugs for neglected diseases. Screening a diverse library of 10,000 drug-like compounds against 7 neglected disease pathogens resulted in an integrated dataset of 744 hits. We discuss the prioritization of these hits for each pathogen and the strong correlation observed between compounds active against more than two pathogens and mammalian cell toxicity. Our work suggests that the efficiency of early drug discovery for neglected diseases can be enhanced through a collaborative, multi-pathogen approach.}
}