%0 Journal Article
%A Bandopadhyay, R
%A Liu, JY
%A Sisodiya, SM
%A Thom, M
%D 2014
%F discovery:1391188
%J Neuropathology and Applied Neurobiology
%K Hippocampal sclerosis, Hirano Bodies, NPY, calbindin, calretinin, dementia, epilepsy, granule cell dispersion, mossy fibre sprouting
%N 2
%P 177-190
%T A Comparative Study of the Dentate Gyrus in Hippocampal Sclerosis in Epilepsy and Dementia.
%U https://discovery-pp.ucl.ac.uk/id/eprint/1391188/
%V 40
%X Hippocampal Sclerosis (HS) is long-recognised in association with epilepsy (HSE ) and more recently in the context of cognitive decline or dementia in the elderly (HSD ), in some cases as a component of neurodegenerative diseases, including Alzheimer's disease (AD) and fronto-temporal lobe dementia (FTLD). There is an increased risk of seizures in AD and spontaneous epileptiform discharges in the dentate gyrus of transgenic AD models; epilepsy can be associated with an age-accelerated increase in AD-type pathology and cognitive decline. The convergence between these disease processes could be related to hippocampal pathology. HSE typically shows re-organisation of both excitatory and inhibitory neuronal networks in the dentate gyrus, and is considered to be relevant to hippocampal excitability. We sought to compare the pathology of HSE and HSD , focusing on re-organisation in the dentate gyrus.
%Z © 2013 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd 177  on behalf of British Neuropathological Society.  This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and  distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are  made.