eprintid: 1406784 rev_number: 38 eprint_status: archive userid: 608 dir: disk0/01/40/67/84 datestamp: 2013-09-24 19:02:21 lastmod: 2021-09-19 23:22:17 status_changed: 2013-09-24 19:02:21 type: article metadata_visibility: show item_issues_count: 0 creators_name: Schiavo, G creators_name: Greensmith, L creators_name: Hafezparast, M creators_name: Fisher, EM title: Cytoplasmic dynein heavy chain: the servant of many masters. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F85 keywords: Cramping 1, Legs at odd angles, Sprawling, amyotrophic lateral sclerosis, axonal transport, motor neurons, neurodegeneration note: �© 2013 The Authors. Published by Elsevier Ltd. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. abstract: Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex comprises different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. Cytoplasmic dynein is particularly important for neurons because it carries essential signals and organelles from distal sites to the cell body. In the past decade, several mouse models have helped to dissect the numerous functions of DYNC1H1. Additionally, several DYNC1H1 mutations have recently been found in human patients that give rise to a broad spectrum of developmental and midlife-onset disorders. Here, we discuss the effects of mutations of mouse and human DYNC1H1 and how these studies are giving us new insight into the many critical roles DYNC1H1 plays in the nervous system. date: 2013-11 official_url: http://dx.doi.org/10.1016/j.tins.2013.08.001 vfaculties: VFBRS vfaculties: VFBRS oa_status: green full_text_type: pub primo: open primo_central: open_green article_type_text: JOURNAL ARTICLE verified: verified_manual elements_source: PubMed elements_id: 901728 doi: 10.1016/j.tins.2013.08.001 pii: S0166-2236(13)00137-9 language_elements: ENG lyricists_name: Fisher, Elizabeth lyricists_name: Greensmith, Linda lyricists_name: Schiavo, Giampietro lyricists_id: EMCFI97 lyricists_id: LGREE07 lyricists_id: GSCHI71 full_text_status: public publication: Trends Neurosci volume: 36 number: 11 pagerange: 641-651 citation: Schiavo, G; Greensmith, L; Hafezparast, M; Fisher, EM; (2013) Cytoplasmic dynein heavy chain: the servant of many masters. Trends Neurosci , 36 (11) pp. 641-651. 10.1016/j.tins.2013.08.001 <https://doi.org/10.1016/j.tins.2013.08.001>. Green open access document_url: https://discovery-pp.ucl.ac.uk/id/eprint/1406784/1/1-s2.0-S0166223613001379-main.pdf