eprintid: 1406784
rev_number: 38
eprint_status: archive
userid: 608
dir: disk0/01/40/67/84
datestamp: 2013-09-24 19:02:21
lastmod: 2021-09-19 23:22:17
status_changed: 2013-09-24 19:02:21
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Schiavo, G
creators_name: Greensmith, L
creators_name: Hafezparast, M
creators_name: Fisher, EM
title: Cytoplasmic dynein heavy chain: the servant of many masters.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F85
keywords: Cramping 1, Legs at odd angles, Sprawling, amyotrophic lateral sclerosis, axonal transport, motor neurons, neurodegeneration
note: �© 2013 The Authors. Published by Elsevier Ltd. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons
Attribution License, which permits unrestricted use, distribution and reproduction
in any medium, provided the original author and source are credited.
abstract: Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex comprises different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. Cytoplasmic dynein is particularly important for neurons because it carries essential signals and organelles from distal sites to the cell body. In the past decade, several mouse models have helped to dissect the numerous functions of DYNC1H1. Additionally, several DYNC1H1 mutations have recently been found in human patients that give rise to a broad spectrum of developmental and midlife-onset disorders. Here, we discuss the effects of mutations of mouse and human DYNC1H1 and how these studies are giving us new insight into the many critical roles DYNC1H1 plays in the nervous system.
date: 2013-11
official_url: http://dx.doi.org/10.1016/j.tins.2013.08.001
vfaculties: VFBRS
vfaculties: VFBRS
oa_status: green
full_text_type: pub
primo: open
primo_central: open_green
article_type_text: JOURNAL ARTICLE
verified: verified_manual
elements_source: PubMed
elements_id: 901728
doi: 10.1016/j.tins.2013.08.001
pii: S0166-2236(13)00137-9
language_elements: ENG
lyricists_name: Fisher, Elizabeth
lyricists_name: Greensmith, Linda
lyricists_name: Schiavo, Giampietro
lyricists_id: EMCFI97
lyricists_id: LGREE07
lyricists_id: GSCHI71
full_text_status: public
publication: Trends Neurosci
volume: 36
number: 11
pagerange: 641-651
citation:        Schiavo, G;    Greensmith, L;    Hafezparast, M;    Fisher, EM;      (2013)    Cytoplasmic dynein heavy chain: the servant of many masters.                   Trends Neurosci , 36  (11)   pp. 641-651.    10.1016/j.tins.2013.08.001 <https://doi.org/10.1016/j.tins.2013.08.001>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/1406784/1/1-s2.0-S0166223613001379-main.pdf