%J Synlett
%N 3
%K Aldehydes, Palladium, Suzuki, Aromatic compounds, Formylation
%O © Georg Thieme Verlag Stuttgart · New York
%X This letter describes a convenient synthesis of the six isomeric tri- and tetramethylbenzaldehydes, which are not readily available from major chemical suppliers. Formylation of readily available phenols via electrophilic aromatic substitution provides compounds containing the correct aromatic substitution pattern. ­Suzuki cross-coupling of the corresponding trifluoromethanesulfonates with methylboronic acid then provides the benzaldehydes as single isomers.
%V 25
%A P Dhankher
%A TD Sheppard
%P 381 - 384
%T A Convenient Synthesis of Tri- and Tetramethylbenzaldehydes from Readily Available Phenols
%D 2014
%L discovery1418964