eprintid: 1429311 rev_number: 38 eprint_status: archive userid: 608 dir: disk0/01/42/93/11 datestamp: 2014-05-12 18:41:08 lastmod: 2021-12-13 03:07:23 status_changed: 2014-05-12 18:41:08 type: article metadata_visibility: show item_issues_count: 0 creators_name: Kiguli, S creators_name: Akech, SO creators_name: Mtove, G creators_name: Opoka, RO creators_name: Engoru, C creators_name: Olupot-Olupot, P creators_name: Nyeko, R creators_name: Evans, J creators_name: Crawley, J creators_name: Prevatt, N creators_name: Reyburn, H creators_name: Levin, M creators_name: George, EC creators_name: South, A creators_name: Babiker, AG creators_name: Gibb, DM creators_name: Maitland, K title: WHO guidelines on fluid resuscitation in children: missing the FEAST data. ispublished: pub divisions: UCL divisions: B02 divisions: D65 divisions: J38 keywords: Child, Child, Preschool, Fluid Therapy, Humans, Practice Guidelines as Topic, Shock, Septic, World Health Organization note: This is an Open Access article distributed in accordance with the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/3.0/ abstract: The World Health Organization recommendations on management of common childhood illnesses affect the lives of millions of children admitted to hospital worldwide. Its latest guidelines,1 released in May 2013, continue to recommend rapid fluid resuscitation for septic shock, even though the only large controlled trial of this treatment (Fluid Expansion as a Supportive Treatment (FEAST) found that it increased the risk of death in African children.2 A subsequent systematic review of bolus resuscitation in children with shock resulting from severe infection also did not support its use.3 Failure to take this evidence into account is not consistent with WHO’s commitment to systematically and transparently assess evidence using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) process when producing guidelines and could endanger the lives of children. date: 2014-01-14 official_url: http://dx.doi.org/10.1136/bmj.f7003 vfaculties: VFPHS oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_source: PubMed elements_id: 927153 doi: 10.1136/bmj.f7003 lyricists_name: Babiker, Abdel lyricists_name: George, Elizabeth lyricists_name: Gibb, Diana lyricists_name: South, Annabelle lyricists_id: ABABI41 lyricists_id: ERUSS31 lyricists_id: MGIBB48 lyricists_id: ASOUT21 full_text_status: public publication: BMJ volume: 348 article_number: f7003 event_location: England citation: Kiguli, S; Akech, SO; Mtove, G; Opoka, RO; Engoru, C; Olupot-Olupot, P; Nyeko, R; ... Maitland, K; + view all <#> Kiguli, S; Akech, SO; Mtove, G; Opoka, RO; Engoru, C; Olupot-Olupot, P; Nyeko, R; Evans, J; Crawley, J; Prevatt, N; Reyburn, H; Levin, M; George, EC; South, A; Babiker, AG; Gibb, DM; Maitland, K; - view fewer <#> (2014) WHO guidelines on fluid resuscitation in children: missing the FEAST data. BMJ , 348 , Article f7003. 10.1136/bmj.f7003 <https://doi.org/10.1136/bmj.f7003>. Green open access document_url: https://discovery-pp.ucl.ac.uk/id/eprint/1429311/1/bmj.f7003.full.pdf