eprintid: 1453158
rev_number: 30
eprint_status: archive
userid: 608
dir: disk0/01/45/31/58
datestamp: 2014-10-28 21:46:18
lastmod: 2021-09-25 23:09:33
status_changed: 2014-10-28 21:46:18
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Stephen, TL
creators_name: Gupta-Agarwal, S
creators_name: Kittler, JT
title: Mitochondrial dynamics in astrocytes.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: G02
note: © 2014 The Author(s)
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
abstract: Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca(2+)) levels in response to synaptic activity. Astrocyte Ca(2+) elevations can trigger the release of neuroactive substances that can modulate synaptic transmission and plasticity, hence promoting bidirectional communication with neurons. Intracellular Ca(2+) dynamics can be regulated by several proteins located in the plasma membrane, within the cytosol and by intracellular organelles such as mitochondria. Spatial dynamics and strategic positioning of mitochondria are important for matching local energy provision and Ca(2+) buffering requirements to the demands of neuronal signalling. Although relatively unresolved in astrocytes, further understanding the role of mitochondria in astrocytes may reveal more about the complex bidirectional relationship between astrocytes and neurons in health and disease. In the present review, we discuss some recent insights regarding mitochondrial function, transport and turnover in astrocytes and highlight some important questions that remain to be answered.
date: 2014-10
official_url: http://dx.doi.org/10.1042/BST20140195
vfaculties: VFLS
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article, Research Support, Non-U.S. Gov't
verified: verified_manual
elements_source: PubMed
elements_id: 975497
doi: 10.1042/BST20140195
pii: BST20140195
lyricists_name: Kittler, Josef
lyricists_id: JTJKI61
full_text_status: public
publication: Biochem Soc Trans
volume: 42
number: 5
pagerange: 1302 - 1310
event_location: England
citation:        Stephen, TL;    Gupta-Agarwal, S;    Kittler, JT;      (2014)    Mitochondrial dynamics in astrocytes.                   Biochem Soc Trans , 42  (5)   1302 - 1310.    10.1042/BST20140195 <https://doi.org/10.1042/BST20140195>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/1453158/1/0421302.pdf