eprintid: 1472547
rev_number: 26
eprint_status: archive
userid: 608
dir: disk0/01/47/25/47
datestamp: 2015-11-13 15:44:49
lastmod: 2021-12-13 02:08:13
status_changed: 2015-11-13 15:44:49
type: article
metadata_visibility: show
creators_name: He, Q
creators_name: Duguid, I
creators_name: Clark, B
creators_name: Panzanelli, P
creators_name: Patel, B
creators_name: Thomas, P
creators_name: Fritschy, JM
creators_name: Smart, TG
title: Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: G02
divisions: C10
divisions: D17
divisions: G95
note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
abstract: Inhibitory synaptic plasticity is important for shaping both neuronal excitability and network activity. Here we investigate the input and GABA(A) receptor subunit specificity of inhibitory synaptic plasticity by studying cerebellar interneuron-Purkinje cell (PC) synapses. Depolarizing PCs initiated a long-lasting increase in GABA-mediated synaptic currents. By stimulating individual interneurons, this plasticity was observed at somatodendritic basket cell synapses, but not at distal dendritic stellate cell synapses. Basket cell synapses predominantly express β2-subunit-containing GABA(A) receptors; deletion of the β2-subunit ablates this plasticity, demonstrating its reliance on GABA(A) receptor subunit composition. The increase in synaptic currents is dependent upon an increase in newly synthesized cell surface synaptic GABA(A) receptors and is abolished by preventing CaMKII phosphorylation of GABA(A) receptors. Our results reveal a novel GABA(A) receptor subunit- and input-specific form of inhibitory synaptic plasticity that regulates the temporal firing pattern of the principal output cells of the cerebellum.
date: 2015
date_type: published
official_url: http://dx.doi.org/10.1038/ncomms8364
oa_status: green
full_text_type: pub
pmcid: PMC4518301
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1043828
doi: 10.1038/ncomms8364
pii: ncomms8364
language_elements: eng
lyricists_name: Clark, Beverley
lyricists_name: Smart, Trevor
lyricists_name: Thomas, Philip
lyricists_id: BACLA52
lyricists_id: TSMAR12
lyricists_id: PTHOM42
actors_name: Clark, Beverley
actors_name: Poirier, Elizabeth
actors_id: BACLA52
actors_id: EPPOI23
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: Nat Commun
volume: 6
article_number: 7364
event_location: England
issn: 2041-1723
citation:        He, Q;    Duguid, I;    Clark, B;    Panzanelli, P;    Patel, B;    Thomas, P;    Fritschy, JM;           He, Q;  Duguid, I;  Clark, B;  Panzanelli, P;  Patel, B;  Thomas, P;  Fritschy, JM;  Smart, TG;   - view fewer <#>    (2015)    Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells.                   Nat Commun , 6     , Article 7364.  10.1038/ncomms8364 <https://doi.org/10.1038/ncomms8364>.       Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/1472547/1/Interneuron-%20and%20GABA%28A%29%20receptor-specific%20inhibitory%20synaptic%20plasticity%20in%20cerebellar%20Purkinje%20cells..pdf