TY - JOUR JF - Biochemical Society Transactions UR - http://doi.org/10.1042/BST20160139 TI - Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies EP - 829 SP - 813 KW - Science & Technology KW - Life Sciences & Biomedicine KW - Biochemistry & Molecular Biology KW - COPPER RESPIRATORY OXIDASES KW - PROTON-TRANSFER PATHWAYS KW - ACTIVE-SITE TYROSINE KW - PARACOCCUS-DENITRIFICANS KW - RHODOBACTER-SPHAEROIDES KW - ELECTRON-TRANSFER KW - OXYGEN REDUCTION KW - FTIR SPECTROSCOPY KW - HYDROGEN-PEROXIDE KW - TERMINAL OXIDASES AV - public VL - 45 N2 - Mitochondrial cytochrome c oxidase is a member of a diverse superfamily of haem?copper oxidases. Its mechanism of oxygen reduction is reviewed in terms of the cycle of catalytic intermediates and their likely chemical structures. This reaction cycle is coupled to the translocation of protons across the inner mitochondrial membrane in which it is located. The likely mechanism by which this occurs, derived in significant part from studies of bacterial homologues, is presented. These mechanisms of catalysis and coupling, together with current alternative proposals of underlying mechanisms, are critically reviewed. Y1 - 2017/06// ID - discovery1553109 SN - 1470-8752 A1 - Rich, PR PB - PORTLAND PRESS LTD N1 - © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society. This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. IS - 3 ER -