TY  - JOUR
JF  - Biochemical Society Transactions
UR  - http://doi.org/10.1042/BST20160139
TI  - Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies
EP  - 829
SP  - 813
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Biochemistry & Molecular Biology
KW  -  COPPER RESPIRATORY OXIDASES
KW  -  PROTON-TRANSFER PATHWAYS
KW  -  ACTIVE-SITE TYROSINE
KW  -  PARACOCCUS-DENITRIFICANS
KW  -  RHODOBACTER-SPHAEROIDES
KW  -  ELECTRON-TRANSFER
KW  -  OXYGEN REDUCTION
KW  -  FTIR SPECTROSCOPY
KW  -  HYDROGEN-PEROXIDE
KW  -  TERMINAL OXIDASES
AV  - public
VL  - 45
N2  - Mitochondrial cytochrome c oxidase is a member of a diverse superfamily of haem?copper oxidases. Its mechanism of oxygen reduction is reviewed in terms of the cycle of catalytic intermediates and their likely chemical structures. This reaction cycle is coupled to the translocation of protons across the inner mitochondrial membrane in which it is located. The likely mechanism by which this occurs, derived in significant part from studies of bacterial homologues, is presented. These mechanisms of catalysis and coupling, together with current alternative proposals of underlying mechanisms, are critically reviewed.
Y1  - 2017/06//
ID  - discovery1553109
SN  - 1470-8752
A1  - Rich, PR
PB  - PORTLAND PRESS LTD
N1  - © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society. This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 3
ER  -