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<https://discovery-pp.ucl.ac.uk/id/eprint/18525> <http://purl.org/dc/terms/title> "Microbubbling and microencapsulation by co-axial electrohydrodynamic atomization"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery-pp.ucl.ac.uk/id/eprint/18525> <http://purl.org/ontology/bibo/abstract> "Microbubbles coated with polymers or surfactants have been used in medical imaging\r\nfor several years as ultrasound contrast agent particles and are now being investigated\r\nby researchers as drug and gene delivery vehicles and blood substitutes. Current\r\nmethods available for the preparation of microbubbles are insufficient as they result in\r\nmicrobubbles with a wide size distribution and as such filtration is necessary before\r\ntheir use. With a view to fill the above demand, a detailed investigation has been carried\r\nout in this research to learn the viability of co-axial electrohydrodynamic atomization\r\n(CEHDA) technique to prepare microbubbles. The research also focuses on the effects\r\nof the process parameters such as flow rates, applied voltage and material parameters\r\nsuch as electrical conductivity, surface tension and viscosity with the objective of\r\npreparing polymer or surfactant coated stabilized microbubbles with diameters < 8 μm\r\nand with a narrow size distribution. A model glycerol-air system was used so that the\r\nCEHDA technique was modified to generate suspensions of microbubbles to a diameter\r\n< 8 μm with a narrow size distribution and then to characterise the CEHDA\r\nmicrobubbling process in terms of size and stability with varying process parameters\r\nand material parameters. Construction of a parametric plot between the air flow rate and\r\nthe liquid flow rate was extremely useful in identifying the flow rate regime of air and\r\nliquid or suspension or solution for the continuous microbubbling of the system used.\r\nWith further investigations into the CEHDA microbubbling technique, it was possible\r\nto develop strategies, first, to prepare suspensions of stabilized phospholipids-coated\r\nmicrobubbles with a mean diameter of ~ 5 μm and a polydispersivity index of 9%, and\r\nsecond, polymeric microspheres with a mean diameter of 400 nm and a polydispersivity\r\nindex of 8% using a biocompatible polymer."^^<http://www.w3.org/2001/XMLSchema#string> .
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