eprintid: 8735
rev_number: 48
eprint_status: archive
userid: 598
dir: disk0/00/00/87/35
datestamp: 2008-08-28 14:01:11
lastmod: 2015-07-23 09:34:47
status_changed: 2008-08-28 14:01:11
type: article
metadata_visibility: show
creators_name: Harrison, C.N.
creators_name: Donohoe, S.
creators_name: Carr, P.
creators_name: Dave, M.
creators_name: Mackie, I.
creators_name: Machin, S.J.
creators_id: 
creators_id: 
creators_id: 
creators_id: 
creators_id: IJMAC71
creators_id: SJMAC45
title: Patients with Essential thrombocythaemia have an increased prevalence of antiphospholipid antibodies which may be associated with thrombosis
ispublished: pub
subjects: 3550
divisions: G98
keywords: Antibody, vascular disease, cardiovascular disease, Myeloproliferative syndrome, hemopathy, immunological investigation, human, risk factor, prevalence, IgM, β2 acid-Glycoprotein, phospholipid, autoantibody, autoimmunity, pathogenesis, thrombosis, complication, essential, thrombocythemia
note: Published by Schattauer GmbH
abstract: A significant proportion of patients with Essential Thrombocythaemia (ET) have thrombotic complications which have an important impact upon the quality, and duration of their life. We performed a retrospective cross sectional study of the prevalence of antiphospholipid antibodies (APA) in 68 ET patients. Compared to 200 elderly controls (> 50 years) there was a significant increase in anticardiolipin IgM (p < 0.0001) and anti β2 glycoprotein I (anti-β2GPI) IgM (p < 0.0001) antibodies in ET. Thrombosis occurred in 10/20 with APA and 12/48 without, p = 0.04, relative risk 2.0 (95% confidence intervals 1.03-3.86); these patients did not differ in terms of other clinical features. The prevalence of thrombosis in patients with dual APA (6/7) was significant when compared to those with single APA (p = 0.02) and the remaining patients (p < 0.0002). Also anti-β2GPI IgM antibodies either alone, or in combination with another APA, were associated with thrombosis (p = 0.02). These results suggest that the prevalence of APA in ET and their influence upon thrombotic risk merit investigation in a larger study.
date: 2002-05
date_type: published
official_url: http://www.schattauer.de/index.php?id=832&L=1&no_cache=1&artikel=11837
vfaculties: VGHCSCI
rae2008: 4
oa_status: green
language: eng
primo: open
primo_central: open_green
lyricists_name: Mackie, I
lyricists_name: Machin, S
lyricists_id: IJMAC71
lyricists_id: SJMAC45
full_text_status: public
publication: Thrombosis and haemostasis
volume: 87
number: 5
pagerange: 802-807
refereed: TRUE
issn: 0340-6245
citation:        Harrison, C.N.;    Donohoe, S.;    Carr, P.;    Dave, M.;    Mackie, I.;    Machin, S.J.;      (2002)    Patients with Essential thrombocythaemia have an increased prevalence of antiphospholipid antibodies which may be associated with thrombosis.                   Thrombosis and haemostasis , 87  (5)   pp. 802-807.          Green open access   
 
document_url: https://discovery-pp.ucl.ac.uk/id/eprint/8735/1/8735.pdf