Sanda, N;
Cerliani, L;
Authié, CN;
Sabbah, N;
Sahel, JA;
Habas, C;
Safran, AB;
(2018)
Visual brain plasticity induced by central and peripheral visual field loss.
Brain Structure and Function
, 223
(7)
pp. 3473-3485.
10.1007/s00429-018-1700-7.
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Abstract
Disorders that specifically affect central and peripheral vision constitute invaluable models to study how the human brain adapts to visual deafferentation. We explored cortical changes after the loss of central or peripheral vision. Cortical thickness (CoTks) and resting-state cortical entropy (rs-CoEn), as a surrogate for neural and synaptic complexity, were extracted in 12 Stargardt macular dystrophy, 12 retinitis pigmentosa (tunnel vision stage), and 14 normally sighted subjects. When compared to controls, both groups with visual loss exhibited decreased CoTks in dorsal area V3d. Peripheral visual field loss also showed a specific CoTks decrease in early visual cortex and ventral area V4, while central visual field loss in dorsal area V3A. Only central visual field loss exhibited increased CoEn in LO-2 area and FG1. Current results revealed biomarkers of brain plasticity within the dorsal and the ventral visual streams following central and peripheral visual field defects.
| Type: | Article |
|---|---|
| Title: | Visual brain plasticity induced by central and peripheral visual field loss |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00429-018-1700-7 |
| Publisher version: | http://doi.org/10.1007/s00429-018-1700-7 |
| Language: | English |
| Additional information: | Copyright information © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10054017 |
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