Kovanda, A;
Leonardis, L;
Zidar, J;
Koritnik, B;
Dolenc-Groselj, L;
Ristic Kovacic, S;
Curk, T;
(2018)
Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls.
Scientific Reports
, 8
, Article 5609. 10.1038/s41598-018-23139-2.
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Abstract
Amyotrophic lateral sclerosis is a late-onset disorder primarily affecting motor neurons and leading to progressive and lethal skeletal muscle atrophy. Small RNAs, including microRNAs (miRNAs), can serve as important regulators of gene expression and can act both globally and in a tissue-/cell-type-specific manner. In muscle, miRNAs called myomiRs govern important processes and are deregulated in various disorders. Several myomiRs have shown promise for therapeutic use in cellular and animal models of ALS; however, the exact miRNA species differentially expressed in muscle tissue of ALS patients remain unknown. Following small RNA-Seq, we compared the expression of small RNAs in muscle tissue of ALS patients and healthy age-matched controls. The identified snoRNAs, mtRNAs and other small RNAs provide possible molecular links between insulin signaling and ALS. Furthermore, the identified miRNAs are predicted to target proteins that are involved in both normal processes and various muscle disorders and indicate muscle tissue is undergoing active reinnervation/compensatory attempts thus providing targets for further research and therapy development in ALS.
| Type: | Article |
|---|---|
| Title: | Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-018-23139-2 |
| Publisher version: | https://doi.org/10.1038/s41598-018-23139-2 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10063981 |
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