Ugai, T;
Kelemen, LE;
Mizuno, M;
Ong, J-S;
Webb, PM;
Chenevix-Trench, G;
Australian Ovarian Cancer Study Group;
... Ovarian Cancer Association Consortium; + view all
(2018)
Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.
Cancer Science
, 109
(2)
pp. 435-445.
10.1111/cas.13470.
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Abstract
The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1274 controls of Asian descent with information on recent alcohol consumption. Pooled odds ratios (OR) with 95% confidence intervals (CI) for OvCa risk associated with alcohol consumption, rs671 and their interaction were estimated using logistic regression models adjusted for potential confounders. No significant association was observed for daily alcohol intake with invasive OvCa (OR comparing any consumption to none = 0.83; 95% CI = 0.58-1.18) or with individual histotypes. A significant decreased risk was seen for carriers of one or both Lys alleles of rs671 for invasive mucinous OvCa (OR = 0.44; 95% CI = 0.20-0.97) and for invasive and borderline mucinous tumors combined (OR = 0.48; 95% CI = 0.26-0.89). No significant interaction was observed between alcohol consumption and rs671 genotypes. In conclusion, self-reported alcohol consumption at the quantities estimated was not associated with OvCa risk among Asians. Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype. This association will require replication in a larger sample.
| Type: | Article |
|---|---|
| Title: | Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/cas.13470 |
| Publisher version: | http://doi.org/10.1111/cas.13470 |
| Language: | English |
| Additional information: | Copyright © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | ALDH2, Asian, drinking habit, ovarian cancer, pooled analysis, Adenocarcinoma, Mucinous, Alcohol Drinking, Aldehyde Dehydrogenase, Mitochondrial, Asian Continental Ancestry Group, Cohort Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Logistic Models, Odds Ratio, Ovarian Neoplasms, Polymorphism, Single Nucleotide |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10064025 |
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