Salta, E;
De Strooper, B;
(2017)
microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease.
The FASEB Journal
, 31
(2)
pp. 424-433.
10.1096/fj.201601308.
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Abstract
With the consideration of the broad involvement of microRNAs (miRNAs) in the regulation of molecular networks in the brain, it is not surprising that miRNA dysregulation causes neurodegeneration in animal models. miRNA profiling in the human brain has revealed miR-132 as one of the most severely down-regulated miRNAs at the intermediate and late Braak stages of Alzheimer’s disease (AD), as well as in other neurodegenerative disorders. Suppression of miR-132 aggravates multiple layers of pathology at the molecular and functional level. We describe the potential therapeutic implications of these findings and suggest miRNA targeting or replacement as a realistic multi-hit, therapeutic strategy for AD. Salta, E., De Strooper, B. microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer’s disease.
| Type: | Article |
|---|---|
| Title: | microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease |
| DOI: | 10.1096/fj.201601308 |
| Publisher version: | http://dx.doi.org/10.1096/fj.201601308 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Small RNA, amyloid/TAU pathology, neurodegeneration, neuroprotection, therapy, element-binding protein, neurotrophic factor, amyloid-beta, in-vivo, neurodegenerative disorders, mir-132 expression, neuronal apoptosis, signaling pathway, circadian-clock, down-regulation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/1541546 |
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