Tian, Y;
Morris, TJ;
Webster, AP;
Yang, Z;
Beck, S;
Feber, A;
Teschendorff, AE;
(2017)
ChAMP: Updated Methylation Analysis Pipeline for Illumina BeadChips.
Bioinformatics
, 33
(24)
pp. 3982-3984.
10.1093/bioinformatics/btx513.
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Abstract
Summary: The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high-throughput DNA methylation analysis, effectively doubling the coverage compared to the older 450 K array. Here we present a significantly updated and improved version of the Bioconductor package ChAMP, which can be used to analyze EPIC and 450k data. Many enhanced functionalities have been added, including correction for cell-type heterogeneity, network analysis and a series of interactive graphical user interfaces. / Availability and implementation: ChAMP is a BioC package available from https://bioconductor.org/packages/release/bioc/html/ChAMP.html. / Contact: a.teschendorff@ucl.ac.uk or s.beck@ucl.ac.uk or a.feber@ucl.ac.uk / Supplementary information: Supplementary data are available at Bioinformatics online.
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