Tierney, J;
Vale, CL;
Burdett, S;
Fisher, D;
Rydzewska, L;
Parmar, MKB;
(2017)
Timely and reliable evaluation of the effects of interventions: a framework for adaptive meta-analysis (FAME).
Trials
, 18
(Suppl.1)
, Article P351. 10.1186/s13063-017-1902-y.
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Abstract
Most systematic reviews are retrospective and use aggregate data AD) from publications, meaning they can be unreliable, lag behind therapeutic developments and fail to influence ongoing or new trials. Commonly, the potential influence of unpublished or ongoing trials is overlooked when interpreting results, or determining the value of updating the meta-analysis or need to collect individual participant data (IPD). Therefore, we developed a Framework for Adaptive Metaanalysis (FAME) to determine prospectively the earliest opportunity for reliable AD meta-analysis. We illustrate FAME using two systematic reviews in men with metastatic (M1) and non-metastatic (M0)hormone-sensitive prostate cancer (HSPC).
| Type: | Article |
|---|---|
| Title: | Timely and reliable evaluation of the effects of interventions: a framework for adaptive meta-analysis (FAME) |
| Event: | Society for Clinical Trials Annual Meeting 2017 |
| Location: | Liverpool, UK |
| Dates: | 7-10 May 2017 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s13063-017-1902-y |
| Publisher version: | http://dx.doi.org/10.1186/s13063-017-1902-y |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution Licence, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Medicine, Research & Experimental, Research & Experimental Medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10024519 |
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