Kerminen, S;
Havulinna, AS;
Hellenthal, G;
Martin, AR;
Sarin, A-P;
Perola, M;
Palotie, A;
... Pirinen, M; + view all
(2017)
Fine-Scale Genetic Structure in Finland.
G3: Genes, Genomes, Genetics
, 7
(10)
pp. 3459-3468.
10.1534/g3.117.300217.
Preview |
Text
3459.full.pdf - Published Version Download (1MB) | Preview |
Abstract
Coupling dense genotype data with new computational methods offers unprecedented opportunities for individual-level ancestry estimation once geographically precisely defined reference data sets become available. We study such a reference data set for Finland containing 2376 such individuals from the FINRISK Study survey of 1997 both of whose parents were born close to each other. This sampling strategy focuses on the population structure present in Finland before the 1950s. By using the recent haplotype-based methods ChromoPainter (CP) and FineSTRUCTURE (FS) we reveal a highly geographically clustered genetic structure in Finland and report its connections to the settlement history as well as to the current dialectal regions of the Finnish language. The main genetic division within Finland shows striking concordance with the 1323 borderline of the treaty of Nöteborg. In general, we detect genetic substructure throughout the country, which reflects stronger regional genetic differences in Finland compared to, for example, the UK, which in a similar analysis was dominated by a single unstructured population. We expect that similar population genetic reference data sets will become available for many more populations in the near future with important applications, for example, in forensic genetics and in genetic association studies. With this in mind, we report those extensions of the CP + FS approach that we found most useful in our analyses of the Finnish data.
| Type: | Article |
|---|---|
| Title: | Fine-Scale Genetic Structure in Finland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1534/g3.117.300217 |
| Publisher version: | https://doi.org/10.1534/g3.117.300217 |
| Language: | English |
| Additional information: | Copyright © 2017 Kerminen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, Population Genetics, Population Structure, Haplotype Sharing, Finnish-Disease Heritage, Population-Structure, Founder Population, Association, Variants, Treaty, Rare |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10026099 |
Archive Staff Only
 |
View Item |
