Orubu, S;
Okwelogu, C;
Opanuga, O;
Tuleu, C;
(2018)
A survey of caregivers of Nigerian children less than 6 years of age to determine the experience and perception of acceptability of oral solid dosage forms.
International Journal of Pharmaceutics
, 536
(2)
pp. 582-289.
10.1016/j.ijpharm.2017.10.047.
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Abstract
OBJECTIVES: The World Health Organization (WHO) recommends flexible solid oral dosage forms such as dispersible tablet as the preferred formulation for (young) children, especially in developing/low- and middle-income countries, LMIC. The aim of this study was to assess experience, perceptions of acceptability, and formulation preferences, among 10 oral dosage forms for young children in a sample of end-users in Nigeria as an exemplar LMIC. METHODS: Using a semi-structured and validated questionnaire, 148 caregivers were surveyed. Acceptability was assessed by level of liking using a 3-point Likert scale and ease of administration. Preference was assessed from participants’ dosage form of choice. Oral dosage forms assessed were those mentioned in the British National Formulary for children, 2013. RESULTS: The formulation perceived as the most acceptable was the chewable/suckable tablet. However, preference was for liquids. Specifically with the dispersible tablet, whilst 89% (n = 111) of caregivers of young children found it easy-to-administer, only 50% of children liked it. CONCLUSION: There is a gap between the proposal of dispersible tablet as the preferred dosage form for young children and caregivers’ perceptions of acceptability and preference. Educational strategies to increase acceptability of dispersible tablets as the preferred formulation for young children would be required.
| Type: | Article |
|---|---|
| Title: | A survey of caregivers of Nigerian children less than 6 years of age to determine the experience and perception of acceptability of oral solid dosage forms. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpharm.2017.10.047 |
| Publisher version: | https://doi.org/10.1016/j.ijpharm.2017.10.047 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Flexible solid oral dosage forms; Acceptability; Dosage form preference; Children |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10028810 |
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