Hiratani, N;
Fukai, T;
(2017)
Detailed dendritic excitatory/inhibitory balance through heterosynaptic spike-timing-dependent plasticity.
Journal of Neuroscience
, 37
(50)
pp. 12106-12122.
10.1523/JNEUROSCI.0027-17.2017.
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Abstract
The balance between excitatory and inhibitory inputs is a key feature of cortical dynamics. Such a balance is arguably preserved in dendritic branches, yet its underlying mechanism and functional roles remain unknown. In this study, we developed computational models of heterosynaptic spike-timing-dependent plasticity (STDP) to show that the excitatory/inhibitory balance in dendritic branches is robustly achieved through heterosynaptic interactions between excitatory and inhibitory synapses. The model reproduces key features of experimental heterosynaptic STDP well, and provides analytical insights. Furthermore, heterosynaptic STDP explains how the maturation of inhibitory neurons modulates the selectivity of excitatory neurons for binocular matching in the critical period plasticity. The model also provides an alternative explanation for the potential mechanism underlying the somatic detailed balance that is commonly associated with inhibitory STDP. Our results propose heterosynaptic STDP as a critical factor in synaptic organization and the resultant dendritic computation.
| Type: | Article |
|---|---|
| Title: | Detailed dendritic excitatory/inhibitory balance through heterosynaptic spike-timing-dependent plasticity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.0027-17.2017 |
| Publisher version: | https://doi.org/10.1523/JNEUROSCI.0027-17.2017 |
| Language: | English |
| Additional information: | Copyright remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | critical period, dendritic computation, heterosynaptic plasticity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neurosci Unit |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10028980 |
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