Perretta-Tejedor, N;
Fernandez-Mateos, J;
Garcia-Ortiz, L;
Gomez-Marcos, MA;
Recio-Rodriguez, JI;
Agudo-Conde, C;
Rodriguez-Sanchez, E;
... Martinez-Salgado, C; + view all
(2017)
Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors.
Scientific Reports
, 7
, Article 41875. 10.1038/srep41875.
![[thumbnail of srep41875.pdf]](https://discovery-pp.ucl.ac.uk/style/images/fileicons/text.png) |
Text
srep41875.pdf - Published Version Download (448kB) |
Abstract
Hypertension, diabetes and obesity are cardiovascular risk factors closely associated to the development of renal and cardiovascular target organ damage. VAV2 and VAV3, members of the VAV family proto-oncogenes, are guanosine nucleotide exchange factors for the Rho and Rac GTPase family, which is related with cardiovascular homeostasis. We have analyzed the relationship between the presence of VAV2 rs602990 and VAV3 rs7528153 polymorphisms with cardiovascular risk factors and target organ damage (heart, vessels and kidney) in 411 subjects. Our results show that being carrier of the T allele in VAV2 rs602990 polymorphism is associated with an increased risk of obesity, reduced levels of ankle-brachial index and diastolic blood pressure and reduced retinal artery caliber. In addition, being carrier of T allele is associated with increased risk of target organ damage in males. On the other hand, being carrier of the T allele in VAV3 rs7528153 polymorphism is associated with a decreased susceptibility of developing a pathologic state composed by the presence of hypertension, diabetes, obesity or cardiovascular damage, and with an increased risk of developing altered basal glycaemia. This is the first report showing an association between VAV2 and VAV3 polymorphisms with cardiovascular risk factors and target organ damage.
| Type: | Article |
|---|---|
| Title: | Association of VAV2 and VAV3 polymorphisms with cardiovascular risk factors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/srep41875 |
| Publisher version: | https://doi.org/10.1038/srep41875 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, NUCLEOTIDE EXCHANGE FACTORS, GLOMERULAR-FILTRATION-RATE, INTIMA-MEDIA THICKNESS, NITRIC-OXIDE SYNTHASE, ATHEROSCLEROSIS RISK, METABOLIC SYNDROME, AXON GUIDANCE, DISEASE, FAMILY, PROTEINS |
| UCL classification: | UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10038518 |
Archive Staff Only
 |
View Item |
