Marshall, A; Celentano, A; Cirillo, N; McCullough, M; Porter, S; (2018) Oral keratinocytes synthesize CTACK: A new insight into the pathophysiology of the oral mucosa. Experimental Dermatology , 27 (2) pp. 207-210. 10.1111/exd.13471.

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Abstract

The skin‐associated chemokine CTACK plays a key role in many inflammatory conditions and could be instrumental in the pathophysiology of tissue‐specific immunological diseases such as oral lichen planus (OLP). In this study, we investigated, by RT‐PCR, ELISA, chemotaxis assays, and fluorescence‐activated cell sorting (FACS), the production of CTACK in oral keratinocytes, its expression in tissues from normal and OLP patients, and its role in T‐cell recruitment.CTACK was produced by the oral epithelium, and it affects chemotaxis of memory CLA+ cells to the oral epithelium. CTACK mRNA was expressed constitutively in primary oral epithelium and was increased during pro‐inflammatory IFN‐γ treatment. We found a constitutive production of CTACK at a protein level in oral primary cells that increased after IFN‐γ treatment. Moreover, we confirmed that CTACK attracts memory T cells and those T cells that express CLA above the level of basal migration.

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